KNDy neurons as the GnRH pulse generator: Recent studies in ruminants.
Peptides
; 164: 171005, 2023 06.
Article
em En
| MEDLINE
| ID: mdl-36990389
ABSTRACT
This review considers three aspects of recent work on the role of KNDy neurons in GnRH pulse generation in ruminants. First, work on basic mechanisms of pulse generation includes several tests of this hypothesis, all of which support it, and evidence that Kiss1r-containing neurons form a positive feedback circuit with the KNDy neural network that strengthen the activity of this network. The second section on pathways mediating external inputs focuses on the influence of nutrition and photoperiod, and describes the evidence supporting roles for proopiomelanocortin (POMC) and agouti-related peptide (AgRP) afferents to KNDy cells in each of these. Finally, we review studies exploring the potential applications of manipulating signaling by kisspeptin, and the other KNDy peptides, to control reproductive function in domestic animals and conclude that, although these approaches show some promise, they do not have major advantages over current practices at this time.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Núcleo Arqueado do Hipotálamo
/
Hormônio Liberador de Gonadotropina
Limite:
Animals
Idioma:
En
Revista:
Peptides
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos