The mitochondrial ATP synthase as an ATP consumer-a surprising therapeutic target.
EMBO J
; 42(10): e114141, 2023 05 15.
Article
em En
| MEDLINE
| ID: mdl-37021792
ABSTRACT
The mitochondrial F1 Fo -ATP synthase uses a rotary mechanism to synthesise ATP. This mechanism can, however, also operate in reverse, pumping protons at the expense of ATP, with significant potential implications for mitochondrial and age-related diseases. In a recent study, Acin-Perez et al (2023) use an elegant assay to screen compounds for the capacity to selectively inhibit ATP hydrolysis without affecting ATP synthesis. They show that (+)-epicatechin is one such compound and has significant benefits for cell and tissue function in disease models. These findings signpost a novel therapeutic approach for mitochondrial disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trifosfato de Adenosina
/
ATPases Mitocondriais Próton-Translocadoras
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
EMBO J
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Reino Unido