Using a Metabotype Framework to Deliver Personalized Nutrition Improves Dietary Quality and Metabolic Health Parameters: A 12-Week Randomized Controlled Trial.
Mol Nutr Food Res
; 67(10): e2200620, 2023 05.
Article
em En
| MEDLINE
| ID: mdl-37038841
ABSTRACT
SCOPE Effective strategies for tailoring dietary advice to individuals are urgently needed. The effectiveness of personalized nutrition advice delivered using a metabotype framework in improving dietary quality and metabolic health biomarkers compared to population-level advice is investigated. MATERIALS AND RESULTS:
A 12-week parallel randomized controlled trial is performed with 107 healthy adults. Individuals in the personalized group are classified into metabotypes using four markers (triacylglycerol, high-density lipoprotein [HDL]-cholesterol, total cholesterol [TC], and glucose) and received dietary advice from decision tree algorithms containing metabotypes characteristics and individual traits. Individuals in the control group received generic dietary advice based on national guidelines. The personalized approach results in higher dietary quality assessed by the Alternate Mediterranean Diet Score (effect size [95% confidence interval, CI], 0.77 [0.07, 1.48], 12% versus 3% increase) and significantly lower concentrations of triacylglycerol (-0.17 [-0.28, -0.06] log10 mmol L-1 ), TC (-0.42 [-0.74, -0.10] mmol L-1 ), low-density lipoprotein (LDL)-cholesterol (-0.34, [-0.60, -0.09] mmol L-1 ), and lower triacylglycerol-glucose index (-0.40, [-0.67, -0.13]). Sixteen phosphatidylcholines and six lysophosphatidylcholines, predominately with chain lengths of 30-36 carbons, are lower in the personalized group.CONCLUSIONS:
Personalized nutrition advice delivered using the metabotype framework is effective to improve dietary quality, which could result in reduced CVD risk, and metabolic heath biomarkers.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Colesterol
/
Dieta Mediterrânea
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Mol Nutr Food Res
Assunto da revista:
CIENCIAS DA NUTRICAO
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Irlanda