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A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes.
Pao, Ping-Chieh; Seo, Jinsoo; Lee, Audrey; Kritskiy, Oleg; Patnaik, Debasis; Penney, Jay; Raju, Ravikiran M; Geigenmuller, Ute; Silva, M Catarina; Lucente, Diane E; Gusella, James F; Dickerson, Bradford C; Loon, Anjanet; Yu, Margaret X; Bula, Michael; Yu, Melody; Haggarty, Stephen J; Tsai, Li-Huei.
Afiliação
  • Pao PC; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Seo J; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Lee A; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Kritskiy O; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Patnaik D; Department of Brain Sciences, Daegu Gyeongbuk Institute for Science and Technology, Daegu 42988, South Korea.
  • Penney J; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Raju RM; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Geigenmuller U; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Silva MC; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Lucente DE; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
  • Gusella JF; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Dickerson BC; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Loon A; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Yu MX; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Bula M; Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
  • Yu M; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Haggarty SJ; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Tsai LH; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Proc Natl Acad Sci U S A ; 120(16): e2217864120, 2023 04 18.
Article em En | MEDLINE | ID: mdl-37043533

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Quinase 5 Dependente de Ciclina Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Quinase 5 Dependente de Ciclina Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article