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Application of population physiologically based pharmacokinetic modelling to optimize target expression and clearance mechanisms of therapeutic monoclonal antibodies.
Reig-Lopez, Javier; Tang, Weifeng; Fernandez-Teruel, Carlos; Merino-Sanjuan, Matilde; Mangas-Sanjuan, Victor; Boulton, David W; Sharma, Pradeep.
Afiliação
  • Reig-Lopez J; Pharmacy and Pharmaceutical Technology and Parasitology Department, Faculty of Pharmacy, University of Valencia, Valencia, Spain.
  • Tang W; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
  • Fernandez-Teruel C; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gaithersburg, Maryland, USA.
  • Merino-Sanjuan M; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
  • Mangas-Sanjuan V; Pharmacy and Pharmaceutical Technology and Parasitology Department, Faculty of Pharmacy, University of Valencia, Valencia, Spain.
  • Boulton DW; Interuniversity Research Institute for Molecular Recognition and Technological Development, Polytechnic University of Valencia-University of Valencia, Valencia, Spain.
  • Sharma P; Pharmacy and Pharmaceutical Technology and Parasitology Department, Faculty of Pharmacy, University of Valencia, Valencia, Spain.
Br J Clin Pharmacol ; 89(9): 2691-2702, 2023 09.
Article em En | MEDLINE | ID: mdl-37055941
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Modelos Biológicos / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Espanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Modelos Biológicos / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Espanha