Word production and comprehension in frontotemporal degeneration: A neurocognitive computational Pickian account.

ABSTRACT

Over a century ago, Arnold Pick reported deterioration of word production and comprehension in frontotemporal degeneration, now a common finding. Individuals with semantic dementia (SD) and behavioral variant frontotemporal dementia (bvFTD) present with word retrieval difficulty, while their comprehension is less affected. Computational models have illuminated naming and comprehension in poststroke and progressive aphasias, including SD, but there are no simulations for bvFTD. Here, the WEAVER++/ARC model, previously applied to poststroke and progressive aphasias, is extended to bvFTD. Simulations tested the hypothesis of a loss of activation capacity in semantic memory in SD and bvFTD, caused by network atrophy (Pick, 1908a). The outcomes revealed that capacity loss explains 97% of the variance in naming and comprehension of 100 individual patients. Moreover, capacity loss correlates with individual ratings of atrophy in the left anterior temporal lobe. These results support a unified account of word production and comprehension in SD and bvFTD.