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Expert Consensus on the Use of On-Demand Treatments for OFF Episodes in Parkinson's Disease: A Modified Delphi Panel.
Isaacson, Stuart H; Achari, Madhureeta; Bhidayasiri, Roongroj; Comella, Cynthia; Farmer, Jill Giordano; Gupta, Fiona; Jones, Sarah; Kreitzman, David; Kremens, Daniel; Lewis, Simon J G; Poewe, Werner; Tolosa, Eduardo; Campos, Cynthia; Gibbs, Sarah N; Broder, Michael S.
Afiliação
  • Isaacson SH; Parkinson's Disease and Movement Disorders Center of Boca Raton Boca Raton Florida USA.
  • Achari M; Integrated Neurology PA, Department of Physical Medicine and Rehabilitation McGovern Medical School, University of Texas Houston Texas USA.
  • Bhidayasiri R; Chulalongkorn Centre of Excellence for Parkinson's Disease and Related Disorders, Department of Medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society Bangkok Thailand.
  • Comella C; The Academy of Science The Royal Society of Thailand Bangkok Thailand.
  • Farmer JG; Department of Neurosurgery and Neurological Sciences Rush University Medical Center Chicago Illinois USA.
  • Gupta F; Global Neuroscience Institute Pennington New Jersey USA.
  • Jones S; Department of Neurology Drexel College of Medicine Philadelphia Pennsylvania USA.
  • Kreitzman D; Department of Neurology, Mount Sinai Medical Center Mount Sinai Beth Israel Morningside, Sinai West, The Mount Sinai Hospital New York City New York USA.
  • Kremens D; Parkinson and Movement Disorder Alliance Tucson Arizona USA.
  • Lewis SJG; Parkinson's Disease and Movement Disorders Center of Long Island Commack New York USA.
  • Poewe W; Department of Neurology Sidney Kimmel Medical College at Jefferson University Philadelphia Pennsylvania USA.
  • Tolosa E; Brain and Mind Center, School of Medical Sciences University of Sydney Sydney New South Wales Australia.
  • Campos C; Department of Neurology Medical University of Innsbruck Innsbruck Austria.
  • Gibbs SN; Parkinson's Disease Research Program University of Barcelona Barcelona Spain.
  • Broder MS; PHAR Beverly Hills California USA.
Mov Disord Clin Pract ; 10(4): 652-657, 2023 Apr.
Article em En | MEDLINE | ID: mdl-37070052
ABSTRACT

Background:

On-demand treatments can treat OFF episodes in Parkinson's disease, however, there is limited information regarding when to prescribe them.

Objective:

Develop expert consensus to determine appropriate clinical factors for considering on-demand treatments.

Methods:

Using a RAND/UCLA modified Delphi panel method, a panel developed consensus on the use of on-demand treatments for OFF episodes.

Results:

The panel agreed on-demand treatments were appropriate when OFF episodes were associated with greater functional impact and interfered with basic daily activities. The panel also agreed on-demand treatment may be appropriate for patients with morning akinesia and/or delayed ON of first levodopa dose and >1 type of OFF episode (eg, early morning OFF or wearing OFF regardless of frequency).

Conclusions:

Experts agreed on-demand treatment is appropriate for many patients with OFF episodes. The greater the functional impact of OFF episodes, the more likely experts agreed that on-demand treatment is appropriate to prescribe.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Mov Disord Clin Pract Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Mov Disord Clin Pract Ano de publicação: 2023 Tipo de documento: Article