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Topical Nanotherapeutics for Treating MRSA-Associated Skin and Soft Tissue Infection (SSTIs).
Karnam, Sriravali; Jindal, Anil B; Agnihotri, Charu; Singh, Bhim Pratap; Paul, Atish T.
Afiliação
  • Karnam S; Department of Pharmacy, Birla Institute of Technology and Sciences Pilani (BITS-Pilani), Pilani Campus, Vidyavihar, Pilani, 333031, Rajasthan, India.
  • Jindal AB; Department of Pharmacy, Birla Institute of Technology and Sciences Pilani (BITS-Pilani), Pilani Campus, Vidyavihar, Pilani, 333031, Rajasthan, India.
  • Agnihotri C; Department of Agriculture & Environmental Sciences (AES), Technology Entrepreneurship & Management (NIFTEM), National Institute of Food, Sonipat, 131028, Haryana, India.
  • Singh BP; Department of Agriculture & Environmental Sciences (AES), Technology Entrepreneurship & Management (NIFTEM), National Institute of Food, Sonipat, 131028, Haryana, India. bpsingh@niftem.ac.in.
  • Paul AT; Department of Pharmacy, Birla Institute of Technology and Sciences Pilani (BITS-Pilani), Pilani Campus, Vidyavihar, Pilani, 333031, Rajasthan, India. atish.paul@pilani.bits-pilani.ac.in.
AAPS PharmSciTech ; 24(5): 108, 2023 Apr 26.
Article em En | MEDLINE | ID: mdl-37100956
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) imposes a major challenge for the treatment of infectious diseases with existing antibiotics. MRSA associated with superficial skin and soft tissue infections (SSTIs) is one of them, affecting the skin's superficial layers, and it includes impetigo, folliculitis, cellulitis, furuncles, abscesses, surgical site infections, etc. The efficient care of superficial SSTIs caused by MRSA necessitates local administration of antibiotics, because oral antibiotics does not produce the required concentration at the local site. The topical administration of nanocarriers has been emerging in the area of drug delivery due to its advantages over conventional topical formulation. It enhances the solubility and permeation of the antibiotics into deeper layer of the skin. Apart from this, antibiotic resistance is something that needs to be combated on multiple fronts, and antibiotics encapsulated in nanocarriers help to do so by increasing the therapeutic efficacy in a number of different ways. The current review provides an overview of the resistance mechanism in S. aureus as well as various nanocarriers reported for the effective management of MRSA-associated superficial SSTIs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Infecções Comunitárias Adquiridas / Infecções dos Tecidos Moles / Staphylococcus aureus Resistente à Meticilina Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: AAPS PharmSciTech Assunto da revista: FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Índia

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Infecções Comunitárias Adquiridas / Infecções dos Tecidos Moles / Staphylococcus aureus Resistente à Meticilina Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: AAPS PharmSciTech Assunto da revista: FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Índia