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Local active gingival immunization by a 3,800-molecular-weight streptococcal antigen in protection against dental caries.
Infect Immun ; 52(3): 682-7, 1986 Jun.
Article em En | MEDLINE | ID: mdl-3710580
Local gingival immunization was attempted in an effort to confine the immune response to the oral cavity and bypass the systemic immune response. A low-molecular-weight (3.8K) streptococcal antigen (SA) I/II was applied 10 times over a period of 1 year to the gingival crevices of rhesus monkeys. The antigen was maintained in situ by means of silicone rubber appliances. Serial examinations over a period of 1 year showed that topical gingival immunization with the 3.8K SA results in a significantly lower incidence of dental caries and colonization of Streptococcus mutans compared with that of the sham-immunized controls. This was associated with an increase in gingival crevicular immunoglobulin G and salivary immunoglobulin A anti-SA I/II antibodies, whereas no change occurred in serum antibodies to SA I/II. The immune mechanism which prevents the colonization of S. mutans and the development of caries may involve antibodies that prevent the adherence of S. mutans to the teeth and facilitate phagocytosis and killing by the local neutrophils. This novel route of local immunization is noninvasive, does not cause side effects, and bypasses systemic immunization.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptococcus mutans / Cárie Dentária / Gengiva Limite: Animals Idioma: En Revista: Infect Immun Ano de publicação: 1986 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptococcus mutans / Cárie Dentária / Gengiva Limite: Animals Idioma: En Revista: Infect Immun Ano de publicação: 1986 Tipo de documento: Article