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Nanotransducer-Enabled Wireless Spatiotemporal Tuning of Engineered Bacteria in Bumblebee.
Cheng, Xiaowen; Wang, Chen; Yang, Junzhu; Liu, Dong; Liao, Yuting; Wang, Bin; Han, Sanyang; Zhang, Xue; Zheng, Hao; Lu, Yuan.
Afiliação
  • Cheng X; College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
  • Wang C; Key Laboratory of Industrial Biocatalysis, Ministry of Education, Tsinghua University, Beijing, 100084, China.
  • Yang J; Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China.
  • Liu D; Key Laboratory of Industrial Biocatalysis, Ministry of Education, Tsinghua University, Beijing, 100084, China.
  • Liao Y; Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China.
  • Wang B; Key Laboratory of Industrial Biocatalysis, Ministry of Education, Tsinghua University, Beijing, 100084, China.
  • Han S; Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China.
  • Zhang X; Key Laboratory of Industrial Biocatalysis, Ministry of Education, Tsinghua University, Beijing, 100084, China.
  • Zheng H; Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China.
  • Lu Y; Key Laboratory of Industrial Biocatalysis, Ministry of Education, Tsinghua University, Beijing, 100084, China.
Small ; 19(36): e2301064, 2023 09.
Article em En | MEDLINE | ID: mdl-37127882
Bumblebees are essential pollinators of wild-flowering plants and crops. It is noticed that regulating the gut microorganisms of bumblebees is of great significance for the maintenance of bumblebee health and disease treatment. Additionally, social bees are used as models to study regulatory control methods of gut bacteria in vivo. However, these methods lack precision and are not studied in bumblebees. In this study, nanotransducers are used for wireless spatiotemporal tuning of engineered bacteria in bumblebees. These nanotransducers are designed as 1D chains with smooth surfaces for easy transport in vivo, and temperature-controlled engineered bacteria colonize the guts of microbial-free bumblebees. Thermal production in the bumblebee gut is achieved using magnetothermal and photothermal methods in response to nanotransducers, resulting in significant target protein upregulation in engineered bacteria in the bumblebee gut. This advanced technology enables the precise control of engineered bacteria in the bumblebee gut. It also lays the foundation for the treatment of bumblebee intestinal parasitic diseases and the elimination of pesticide residues.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bactérias / Produtos Agrícolas Limite: Animals Idioma: En Revista: Small Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bactérias / Produtos Agrícolas Limite: Animals Idioma: En Revista: Small Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China