Bioactive secondary metabolites isolated from the soft coral derived <i>Penicillium</i> sp. SCSIO 41038.

Li, Huimin; Long, Jieyi; Wang, Xueni; She, Jianglian; Liu, Yonghong; Li, Yunqiu; Yang, Bin

Bioactive secondary metabolites isolated from the soft coral derived Penicillium sp. SCSIO 41038.

Li, Huimin; Long, Jieyi; Wang, Xueni; She, Jianglian; Liu, Yonghong; Li, Yunqiu; Yang, Bin.

Afiliação

Li H; Pharmacy School of Guilin Medical University, Guilin, P. R. China.
Long J; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. China.
Wang X; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. China.
She J; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. China.
Liu Y; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. China.
Li Y; Pharmacy School of Guilin Medical University, Guilin, P. R. China.
Yang B; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. China.

Nat Prod Res ; : 1-8, 2023 May 02.

Article em En | MEDLINE | ID: mdl-37129009

RESUMO

Chemical investigation of the Penicillium sp. SCSIO 41038 led to the isolation and characterization of one new cyclopiazonic acid-type alkaloid, speradine I (1), and one new phloroglucinol derivative, speradine J (8), along with 13 known compounds. Their structures were determined on the basis of extensive spectroscopic analysis, and by a comparison with data from the literature. All the compounds were evaluated for their antitumor (22Rv1 and PC-3) and enzyme inhibitory activity against acetylcholinesterase (AChE) in vitro.

Palavras-chave

AChE inhibitory activity; Penicillium sp; alkaloid; molecular docking; soft coral

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google