A "Turn-on" Fluorescent Probe Based on Phenothiazine for Selectively Recognizing ClO- and its Practical Applications.
J Fluoresc
; 33(6): 2451-2459, 2023 Nov.
Article
em En
| MEDLINE
| ID: mdl-37129794
ABSTRACT
Hypochlorous acid (HClO), a highly reactive oxygen species, has important effects on human health. High selectivity and sensitivity remain challenges of fluorescent probes for detection of ClO- with a large Stokes shift. This work designed and synthesized a novel phenothiazine-based fluorescent probe TF which can detect ClO- by colorimetric and fluorescent dual signals. TF displayed turn-on fluorescence effect toward ClO- with high selectivity (≥ 28-folds) and sensitivity (LOD = 0.472 µM), fast response time (< 1 min) and large Stokes shift (150 nm) in PBS (pH = 7.4, 40% DMSO). Meanwhile, TF can visualize ClO- on the mung bean sprouts model and apply as testing strips for portable and rapid detecting ClO- by the naked eyes. A phenothiazine-based fluorescent probe with large Stokes shift was synthesized and its responding rapidly ability to detect ClO- was studied.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácido Hipocloroso
/
Corantes Fluorescentes
Limite:
Humans
Idioma:
En
Revista:
J Fluoresc
Assunto da revista:
BIOFISICA
Ano de publicação:
2023
Tipo de documento:
Article