Bilayer STING goes head to head to stay put.
Mol Cell
; 83(9): 1372-1374, 2023 05 04.
Article
em En
| MEDLINE
| ID: mdl-37146568
ABSTRACT
In this issue, Liu et al.1 provide structural insights into how STING remains inactive. Apo-STING adopts a bilayer conformation exhibiting head-to-head and side-to-side interactions in its autoinhibitory state on the ER. The apo-STING oligomer differs from the activated STING oligomer in its biochemical stability, protein domain contact, and membrane curvature.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana
Idioma:
En
Revista:
Mol Cell
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos