A new cell line based coculture system for skin sensitisation testing in one single assay using T cells, aryl hydrocarbon receptor knockout, and co-inhibitory blockage.

Sonnenburg, Anna; Stahlmann, Ralf; Kreutz, Reinhold; Peiser, Matthias

A new cell line based coculture system for skin sensitisation testing in one single assay using T cells, aryl hydrocarbon receptor knockout, and co-inhibitory blockage.

Sonnenburg, Anna; Stahlmann, Ralf; Kreutz, Reinhold; Peiser, Matthias.

Afiliação

Sonnenburg A; Institute for Clinical Pharmacology and Toxicology, Charité-Universitätsmedizin Berlin, Berlin, Germany. anna.sonnenburg@bfr.bund.de.
Stahlmann R; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany. anna.sonnenburg@bfr.bund.de.
Kreutz R; Department Pesticides Safety, German Federal Institute for Risk Assessment, Berlin, Germany. anna.sonnenburg@bfr.bund.de.
Peiser M; Institute for Clinical Pharmacology and Toxicology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Arch Toxicol ; 97(6): 1677-1689, 2023 06.

Article em En | MEDLINE | ID: mdl-37147507

Assuntos

Técnicas de Cocultura; Receptores de Hidrocarboneto Arílico; Biomarcadores/metabolismo; Linhagem Celular; Dinitroclorobenzeno; Receptores de Hidrocarboneto Arílico/genética; Células THP-1; Humanos; Células Jurkat; Testes Cutâneos

Palavras-chave

AhR knockout; Anti-PD-L1; CRISPR/Cas; New approach methodologies; Skin sensitisation; T cell activation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Hidrocarboneto Arílico / Técnicas de Cocultura Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Arch Toxicol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha

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