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Value of contrast-enhanced MR angiography for the follow-up of treated brain arteriovenous malformations: systematic review and meta-analysis.
Zhuo, Yudi; Chang, Jingling; Chen, Yi; Wen, Chunli; Chen, Fei; Li, Wenhui; Gao, Mengxia; Luo, Weibo; Wan, Shurun; Song, Lianying; Zhu, Lingqun.
Afiliação
  • Zhuo Y; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
  • Chang J; Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
  • Chen Y; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
  • Wen C; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
  • Chen F; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
  • Li W; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
  • Gao M; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
  • Luo W; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
  • Wan S; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
  • Song L; Department of Radiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. sssuuuiii2005@163.com.
  • Zhu L; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. lingqunzh@vip.sina.com.
Eur Radiol ; 33(10): 7139-7148, 2023 Oct.
Article em En | MEDLINE | ID: mdl-37148354
ABSTRACT

OBJECTIVE:

To estimate the diagnostic value of contrast-enhanced MR angiography (CE-MRA) in identifying residual brain arteriovenous malformations (AVMs) after treatment.

METHODS:

We retrieved appropriate references from the electronic databases of PubMed, Web of Science, Embase, and Cochrane Library, and then evaluated the methodology quality of included references using the QUADAS-2 tool. We calculated the pooled sensitivity and specificity by applying a bivariate mixed-effects model and detected the publication bias using Deeks' funnel plot. The values of I2 were used to test heterogeneity and meta-regression analyses were performed to search for the causes of heterogeneity.

RESULTS:

We included 7 eligible studies containing 223 participants. Compared with a gold standard, the overall sensitivity and specificity of CE-MRA in detecting residual brain AVMs were 0.77 (95% CI 0.65-0.86) and 0.97 (95% CI 0.82-1.00), respectively. Based on the summary ROC curve, the AUC was 0.89 (95% CI 0.86-0.92). Heterogeneity could be observed in our study, especially for the specificity (I2 = 74.23%). Furthermore, there was no evidence of publication bias.

CONCLUSIONS:

Our study provides evidence that CE-MRA has good diagnostic value and specificity for the follow-up of treated brain AVMs. Nevertheless, considering the small sample size, heterogeneity, and many factors that may affect the diagnostic accuracy, future large-sample, prospective studies are necessary to validate the results. KEY POINTS • The pooled sensitivity and specificity of contrast-enhanced MR angiography (CE-MRA) in detecting residual arteriovenous malformations (AVMs) were 0.77 (95% CI 0.65-0.86) and 0.97 (95% CI 0.82-1.00). • The four-dimensional CE-MRA showed less sensitivity than the three-dimensional CE-MRA for treated AVMs. • CE-MRA is helpful to identify residual AVMs and reduce excessive DSA during follow-up.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Malformações Arteriovenosas / Angiografia por Ressonância Magnética Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Eur Radiol Assunto da revista: RADIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Malformações Arteriovenosas / Angiografia por Ressonância Magnética Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Eur Radiol Assunto da revista: RADIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China