Polygenic risk score for problematic alcohol use predicts heavy drinking and alcohol use disorder symptoms in young adulthood after accounting for adolescent alcohol use and parental alcohol use disorder.

Wang, Frances L; Hicks, Brian M; Zhou, Hang; Kranzler, Henry R; Gelernter, Joel; Zucker, Robert A

Wang, Frances L; Hicks, Brian M; Zhou, Hang; Kranzler, Henry R; Gelernter, Joel; Zucker, Robert A.

Afiliação

Wang FL; Department of Psychiatry, University of Pittsburgh, 3811 O'Hara St, Pittsburgh, PA15213, United States. Electronic address: wangfl@upmc.edu.
Hicks BM; Department of Psychiatry, University of Michigan, 4250 Plymouth Rd, Ann Arbor, MI48109, United States.
Zhou H; Department of Psychiatry, Yale University, 300 George St, New Haven, CT06511, United States; Veterans Affairs Connecticut Healthcare System, West Haven, CT06516, United States.
Kranzler HR; Mental Illness Research, Education and Clinical Center, Crescenz VAMC and Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Philadelphia, PA19104, United States.
Gelernter J; Department of Psychiatry, Yale University, 300 George St, New Haven, CT06511, United States; Veterans Affairs Connecticut Healthcare System, West Haven, CT06516, United States.
Zucker RA; Department of Psychiatry, University of Michigan, 4250 Plymouth Rd, Ann Arbor, MI48109, United States.

Drug Alcohol Depend ; 248: 109909, 2023 Jul 01.

Article em En | MEDLINE | ID: mdl-37163864

Assuntos

Transtornos Relacionados ao Uso de Álcool; Alcoolismo; Consumo de Álcool por Menores; Adolescente; Humanos; Adulto Jovem; Adulto; Criança; Alcoolismo/epidemiologia; Alcoolismo/genética; Estudos Longitudinais; Estudo de Associação Genômica Ampla; Estudos Prospectivos; Teorema de Bayes; Consumo de Bebidas Alcoólicas/epidemiologia; Consumo de Bebidas Alcoólicas/genética; Fatores de Risco; Transtornos Relacionados ao Uso de Álcool/epidemiologia; Transtornos Relacionados ao Uso de Álcool/genética; Pais

Palavras-chave

Family history, adolescent drinking; Polygenic risk score; Problematic alcohol use

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Relacionados ao Uso de Álcool / Alcoolismo / Consumo de Álcool por Menores Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Humans Idioma: En Revista: Drug Alcohol Depend Ano de publicação: 2023 Tipo de documento: Article

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