Corneal confocal microscopy identifies corneal nerve fiber loss in patients with migraine.
Cephalalgia
; 43(5): 3331024231170810, 2023 05.
Article
em En
| MEDLINE
| ID: mdl-37177828
ABSTRACT
BACKGROUND/HYPOTHESIS:
Migraine affects >1 billion people but its pathophysiology remains poorly understood. Alterations in the trigeminovascular system play an important role. We have compared corneal nerve morphology in patients with migraine to healthy controls.METHODS:
Sixty patients with episodic (n = 32) or chronic (n = 28) migraine and 20 age-matched healthy control subjects were studied cross-sectionally. Their migraine characteristics and signs and symptoms of dry eyes were assessed. Manual and automated quantification of corneal nerves was undertaken by corneal confocal microscopy.RESULTS:
In patients with migraine compared to controls, manual corneal nerve fiber density (P < 0.001), branch density (P = 0.015) and length (P < 0.001); and automated corneal nerve fiber density (P < 0.001), branch density (P < 0.001), length (P < 0.001), total branch density (P < 0.001), nerve fiber area (P < 0.001), nerve fiber width (P = 0.045) and fractal dimension (P < 0.001) were lower. Automated corneal nerve fiber density was higher in patients with episodic migraine and aura (P = 0.010); and fractal dimension (P = 0.029) was lower in patients with more headache days in the last three months. Automated corneal nerve fiber density predicted a significant amount of the observed variance in pain intensity (adjusted r2 = 0.14, partial r = -0.37, P = 0.004) in patients with migraine.CONCLUSIONS:
Corneal confocal microscopy reveals corneal nerve loss in patients with migraine. It may serve as an objective imaging biomarker of neurodegeneration in migraine.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Córnea
/
Transtornos de Enxaqueca
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Cephalalgia
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Turquia