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BPSD Patterns in Patients With Severe Neuropsychiatric Disturbances: Insight From the RECAGE Study.
Cognat, Emmanuel; Sabia, Séverine; Fayel, Alexandra; Lilamand, Matthieu; Handels, Ron; Fascendini, Sara; Bergh, Sverre; Frisoni, Giovanni B; Fabbo, Andrea; Tsolaki, Magdalina; Frölich, Lutz; Peters, Oliver; Merlo, Paola; Ciccone, Alfonso; Mecocci, Patrizia; Dumurgier, Julien; Defanti, Carlo A; Hugon, Jacques; Paquet, Claire.
Afiliação
  • Cognat E; Université Paris Cité (EC, ML, CP, SS, JD, JH), UMR-S 1144, INSERM, Paris, France; Cognitive Neurology Center (EC, AF, ML, JD, JH, CP), AP-HP.Nord, Site Lariboisière Fernand-Widal, Paris, France. Electronic address: emmanuel.cognat@aphp.fr.
  • Sabia S; Université Paris Cité (EC, ML, CP, SS, JD, JH), UMR-S 1144, INSERM, Paris, France; Université Paris Cité (SS, JD), Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France.
  • Fayel A; Université Paris Cité (SS, JD), Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France.
  • Lilamand M; Université Paris Cité (EC, ML, CP, SS, JD, JH), UMR-S 1144, INSERM, Paris, France; Cognitive Neurology Center (EC, AF, ML, JD, JH, CP), AP-HP.Nord, Site Lariboisière Fernand-Widal, Paris, France; Department of Geriatry (ML), AP-HP.Nord, Site Lariboisière Fernand-Widal, Paris, France.
  • Handels R; Alzheimer Centre Limburg (RH), School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
  • Fascendini S; Fondazione Europea di Ricerca Biomedica (FERB Onlus) (SF), Gazzaniga, Italy.
  • Bergh S; The Research Centre for Age-related Functional Decline and Disease (SB), Innlandet Hospital Trust, Ottestad, Norway; The Norwegian National Centre for Aging and Health (SB), Vestfold Hospital Trust, Tønsberg, Norway.
  • Frisoni GB; Memory Clinic (GBF), Geneva University Hospitals, Geneva, Switzerland; Laboratory of Neuroimaging of Aging (LANVIE) (GBF), University of Geneva, Geneva, Switzerland.
  • Fabbo A; Geriatric Service-Cognitive Disorders and Dementia (AF), Department of Primary Care, Health Authority and Services of Modena, Modena, Italy.
  • Tsolaki M; Greek Association of Alzheimer's Disease and Related Disorders (GAADRD) (MT), Thessaloniki, Hellas, Macedonia Greece; First Department of Neurology, School of Medicine (MT), Aristotle University of Thessaloniki (AUTh), Hellas, Macedonia Greece.
  • Frölich L; Department of Geriatric Psychiatry (LF), Central Institute of Mental Health; Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
  • Peters O; Department of Psychiatry (OP), Charité Universitätsmedizin Berlin, Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE) (OP), Berlin, Germany.
  • Merlo P; Neurological Unit (PM), U.V.A. Centre, Humanitas Gavazzeni, Bergamo, Italy.
  • Ciccone A; Department of Neurology with neurosurgical activity and stroke unit (AC), ASST di Mantova, Mantova, Italy.
  • Mecocci P; Section of Gerontology and Geriatrics (PM), Department of Medicine and Surgery, University of Perugia, Perugia, Italy; Clinical Geriatrics (PM), NVS Department, Karolinska Institutet, Stockholm, Sweden.
  • Dumurgier J; Université Paris Cité (EC, ML, CP, SS, JD, JH), UMR-S 1144, INSERM, Paris, France; Cognitive Neurology Center (EC, AF, ML, JD, JH, CP), AP-HP.Nord, Site Lariboisière Fernand-Widal, Paris, France; Université Paris Cité (SS, JD), Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Par
  • Defanti CA; Fondazione Europea di Ricerca Biomedica (FERB Onlus) (SF), Gazzaniga, Italy.
  • Hugon J; Université Paris Cité (EC, ML, CP, SS, JD, JH), UMR-S 1144, INSERM, Paris, France; Cognitive Neurology Center (EC, AF, ML, JD, JH, CP), AP-HP.Nord, Site Lariboisière Fernand-Widal, Paris, France.
  • Paquet C; Université Paris Cité (EC, ML, CP, SS, JD, JH), UMR-S 1144, INSERM, Paris, France; Cognitive Neurology Center (EC, AF, ML, JD, JH, CP), AP-HP.Nord, Site Lariboisière Fernand-Widal, Paris, France.
Am J Geriatr Psychiatry ; 31(8): 633-639, 2023 08.
Article em En | MEDLINE | ID: mdl-37183097
OBJECTIVE: Behavioral and psychological symptoms of dementia (BPSD) profiles vary depending on etiology in patients with mild-to-moderate BPSD. It is not known if similar differences exist in patients with severe BPSD. METHODS: We analyzed data collected at baseline in 398 patients with severe BPSD (NPI ≥ 32) and defined diagnosis of dementia (Alzheimer's disease [AD] 297; frontotemporal dementia [FTD] 39; Lewy body disease/Parkinsonian dementia [LBD/PD] 31; and vascular dementia [VD] 31) included in the European multicenter cohort RECAGE. RESULTS: Mean total NPI was 52.11 (18.55). LBD/PD patients demonstrated more hallucinations, more anxiety and more delusions than patients with other dementia. FTD patients had less delusions and more disinhibition than patients with other neurodegenerative disorders. These profiles overlapped partially with those reported in the literature in patients with less severe symptoms. CONCLUSION: Patients with severe BPSD display different and specific profiles of neuropsychiatric symptoms depending on dementia etiology.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Demência Vascular / Doença por Corpos de Lewy / Demência Frontotemporal / Doença de Alzheimer Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Humans Idioma: En Revista: Am J Geriatr Psychiatry Assunto da revista: GERIATRIA / PSIQUIATRIA Ano de publicação: 2023 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Demência Vascular / Doença por Corpos de Lewy / Demência Frontotemporal / Doença de Alzheimer Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Humans Idioma: En Revista: Am J Geriatr Psychiatry Assunto da revista: GERIATRIA / PSIQUIATRIA Ano de publicação: 2023 Tipo de documento: Article