EAACI Molecular Allergology User's Guide 2.0.
Pediatr Allergy Immunol
; 34 Suppl 28: e13854, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-37186333
ABSTRACT
Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE-mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE-mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well-defined, highly pure molecules for component-resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the "EAACI Molecular Allergology User's Guide" (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state-of-the-art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.
Palavras-chave
IgE; IgE cross-reactivity; allergy; allergy diagnosis; anaphylaxis; asthma; atopic dermatitis; basophil activation test; component-resolved diagnosis; cross-reactive carbohydrates; diagnostic algorithms; food allergy; gibberellin-regulated proteins; lipocalins; microarray; molecular allergology; non-specific lipid transfer proteins; oleosins; pan-allergens; parvalbumins; pathogenesis-related protein family 10; polcalcins; pollen allergy; precision medicine; profilins; seed storage proteins; serum albumins; tropomyosins
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hipersensibilidade
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Pediatr Allergy Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
PEDIATRIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Alemanha