Quantitative NMR analysis of the mechanism and kinetics of chaperone Hsp104 action on amyloid-ß42 aggregation and fibril formation.

Ghosh, Shreya; Tugarinov, Vitali; Clore, G Marius

Ghosh, Shreya; Tugarinov, Vitali; Clore, G Marius.

Afiliação

Ghosh S; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892-0520.
Tugarinov V; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892-0520.
Clore GM; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892-0520.

Proc Natl Acad Sci U S A ; 120(21): e2305823120, 2023 05 23.

Article em En | MEDLINE | ID: mdl-37186848

Assuntos

Doença de Alzheimer; Peptídeos beta-Amiloides; Humanos; Cinética; Peptídeos beta-Amiloides/metabolismo; Amiloide/química; Dobramento de Proteína; Chaperonas Moleculares/metabolismo; Fragmentos de Peptídeos/metabolismo; Doença de Alzheimer/metabolismo

Palavras-chave

NMR spectroscopy; amyloid fibril formation; global fitting; kinetics; substoichiometric inhibition

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Doença de Alzheimer Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article

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