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Weight loss with subcutaneous semaglutide versus other glucagon-like peptide 1 receptor agonists in type 2 diabetes: a systematic review.
Stretton, Brandon; Kovoor, Joshua; Bacchi, Stephen; Chang, Shantel; Ngoi, Benjamin; Murray, Tess; Bristow, Thomas C; Heng, Jonathan; Gupta, Aashray; Ovenden, Christopher; Maddern, Guy; Thompson, Campbell H; Heilbronn, Leonie; Boyd, Mark; Rayner, Christopher; Talley, Nicholas J; Horowtiz, Michael.
Afiliação
  • Stretton B; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Kovoor J; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Bacchi S; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Chang S; School of Medicine, Griffith University, Brisbane, Queensland, Australia.
  • Ngoi B; Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
  • Murray T; Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
  • Bristow TC; Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
  • Heng J; Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
  • Gupta A; Gold Coast University Hospital, Brisbane, Queensland, Australia.
  • Ovenden C; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Maddern G; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Thompson CH; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Heilbronn L; Metabolic Health Unit, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
  • Boyd M; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Rayner C; Northern Adelaide Local Health Network, Adelaide, South Australia, Australia.
  • Talley NJ; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Horowtiz M; Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.
Intern Med J ; 53(8): 1311-1320, 2023 08.
Article em En | MEDLINE | ID: mdl-37189293
ABSTRACT
Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) reduce elevated blood glucose levels and induce weight loss. Multiple GLP-1 RAs and one combined GLP-1/glucose-dependent insulinotropic polypeptide agonist are currently available. This review was conducted with the aim of summarising direct comparisons between subcutaneous semaglutide and other GLP-1 RAs in individuals with type 2 diabetes (T2D), particularly with respect to efficacy for inducing weight loss and improving other markers of metabolic health. This systematic review of PubMed and Embase from inception to early 2022 was registered on PROSPERO and was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Meta-Analysis of Observational Studies in Epidemiology guidelines. Of the 740 records identified in the search, five studies fulfilled the inclusion criteria. Comparators included liraglutide, exenatide, dulaglutide and tirzepatide. In the identified studies, multiple dosing regimens were utilised for semaglutide. Randomised trials support the superior efficacy of semaglutide over other GLP-1 RAs with respect to weight loss in T2D, but tirzepatide is more effective than semaglutide.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Intern Med J Assunto da revista: MEDICINA INTERNA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Intern Med J Assunto da revista: MEDICINA INTERNA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Austrália