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Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.
Vuckovic, Ziva; Wang, Jinan; Pham, Vi; Mobbs, Jesse I; Belousoff, Matthew J; Bhattarai, Apurba; Burger, Wessel A C; Thompson, Geoff; Yeasmin, Mahmuda; Nawaratne, Vindhya; Leach, Katie; van der Westhuizen, Emma T; Khajehali, Elham; Liang, Yi-Lynn; Glukhova, Alisa; Wootten, Denise; Lindsley, Craig W; Tobin, Andrew; Sexton, Patrick; Danev, Radostin; Valant, Celine; Miao, Yinglong; Christopoulos, Arthur; Thal, David M.
Afiliação
  • Vuckovic Z; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Wang J; Center for Computational Biology and Department of Molecular Biosciences, University of Kansas, Lawrence, United States.
  • Pham V; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Mobbs JI; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Belousoff MJ; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Bhattarai A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Burger WAC; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Thompson G; Center for Computational Biology and Department of Molecular Biosciences, University of Kansas, Lawrence, United States.
  • Yeasmin M; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Nawaratne V; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Leach K; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • van der Westhuizen ET; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Khajehali E; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Liang YL; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Glukhova A; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Wootten D; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Lindsley CW; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Tobin A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Sexton P; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Danev R; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Valant C; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Miao Y; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
  • Christopoulos A; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery and Department of Chemistry, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, United States.
  • Thal DM; The Centre for Translational Pharmacology, Advanced Research Centre (ARC), College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Elife ; 122023 05 30.
Article em En | MEDLINE | ID: mdl-37248726
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Muscarínicos / Receptor Muscarínico M4 Limite: Humans Idioma: En Revista: Elife Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Muscarínicos / Receptor Muscarínico M4 Limite: Humans Idioma: En Revista: Elife Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Austrália