Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFR<sup>WT/</sup>EGFR<sup>T790M</sup> inhibitors.

Al-Wahaibi, Lamya H; Mohammed, Anber F; Abdel Rahman, Fatema El-Zahraa S; Abdelrahman, Mostafa H; Gu, Xuyuan; Trembleau, Laurent; Youssif, Bahaa G M

Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFR^WT/EGFR^T790M inhibitors.

Al-Wahaibi, Lamya H; Mohammed, Anber F; Abdel Rahman, Fatema El-Zahraa S; Abdelrahman, Mostafa H; Gu, Xuyuan; Trembleau, Laurent; Youssif, Bahaa G M.

Afiliação

Al-Wahaibi LH; Department of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Mohammed AF; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Abdel Rahman FES; Department of Basic Sciences, Faculty of Oral and Dental Medicine, Nahda University, Beni-Suef, Egypt.
Abdelrahman MH; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Gu X; School of Natural and Computing Sciences, University of Aberdeen, Aberdeen, UK.
Trembleau L; School of Natural and Computing Sciences, University of Aberdeen, Aberdeen, UK.
Youssif BGM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt.

J Enzyme Inhib Med Chem ; 38(1): 2218602, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37254958

Assuntos

Antineoplásicos; Neoplasias Pulmonares; Humanos; Receptores ErbB/metabolismo; Cloridrato de Erlotinib/farmacologia; Cloridrato de Erlotinib/uso terapêutico; Antineoplásicos/química; Inibidores de Proteínas Quinases/química; Desenho de Fármacos; Mutação; Neoplasias Pulmonares/tratamento farmacológico; Estaurosporina/farmacologia; Proliferação de Células; Ensaios de Seleção de Medicamentos Antitumorais; Relação Estrutura-Atividade; Linhagem Celular Tumoral; Simulação de Acoplamento Molecular; Estrutura Molecular

Palavras-chave

ADME; EGFR; Indole; antiproliferative; apoptosis; mutation; resistance

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pulmonares / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Arábia Saudita

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