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Neurobehavioral and Medical Correlates of Autism Screening: 2-Year Outcomes for Infants Born Very Preterm.
Shuster, Coral L; Sheinkopf, Stephen J; McGowan, Elisabeth C; Hofheimer, Julie A; O'Shea, T Michael; Carter, Brian S; Helderman, Jennifer B; Check, Jennifer; Neal, Charles R; Pastyrnak, Steven L; Smith, Lynne M; Loncar, Cynthia; Dansereau, Lynne M; DellaGrotta, Sheri A; Marsit, Carmen; Lester, Barry M.
Afiliação
  • Shuster CL; Department of Pediatrics, Women and Infants Hospital, Providence, RI. Electronic address: CShuster@wihri.org.
  • Sheinkopf SJ; Thompson Center for Autism and Neurodevelopment, University of Missouri, Columbia, MO.
  • McGowan EC; Department of Pediatrics, Brown Alpert Medical School, Providence, RI.
  • Hofheimer JA; Deparment of Pediatrics, UNC School of Medicine, Chapel Hill, NC.
  • O'Shea TM; Deparment of Pediatrics, UNC School of Medicine, Chapel Hill, NC.
  • Carter BS; Department of Pediatrics, Children's Mercy Hospital, Kansas City, MO.
  • Helderman JB; Department of Pediatrics, Wake Forest School of Medicine, Winston-Salem, NC.
  • Check J; Department of Pediatrics, Wake Forest School of Medicine, Winston-Salem, NC.
  • Neal CR; Department of Pediatrics, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI.
  • Pastyrnak SL; Department of Pediatrics, Spectrum Health-Helen Devos Hospital, Grand Rapids, MI.
  • Smith LM; Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA.
  • Loncar C; Department of Pediatrics, Brown Alpert Medical School, Providence, RI; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI.
  • Dansereau LM; Department of Pediatrics, Women and Infants Hospital, Providence, RI.
  • DellaGrotta SA; Department of Pediatrics, Women and Infants Hospital, Providence, RI.
  • Marsit C; Gangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA.
  • Lester BM; Department of Pediatrics, Women and Infants Hospital, Providence, RI; Department of Pediatrics, Brown Alpert Medical School, Providence, RI; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI.
J Pediatr ; 260: 113536, 2023 09.
Article em En | MEDLINE | ID: mdl-37271496
OBJECTIVE: To identify neonatal characteristics and 2-year neurodevelopmental outcomes associated with positive screening for risk of autism. STUDY DESIGN: Nine university-affiliated neonatal intensive care units (NICUs) enrolled infants born at <30 weeks of gestation. Infants underwent the NICU Network Neurobehavioral Scale examination before discharge and the Bayley Scales of Infant and Toddler Development, Third Edition, the Child Behavior Checklist, and the Modified Checklist for Autism in Toddlers, revised with follow-up (M-CHAT-R/F) at 2 years of corrected age. Generalized estimating equations examined associations between M-CHAT-R/F, neurobehavioral test results, and neonatal medical morbidities. RESULTS: At 2 years of corrected age, data were available for 466 of 744 enrolled infants without cerebral palsy. Infants with hypoaroused NICU Network Neurobehavioral Scale profiles were more likely to screen M-CHAT-R/F-positive (OR 2.76, 95% CI 1.38-5.54). Infants with ≥2 medical morbidities also were more likely to screen positive (OR 2.65, 95% CI 1.27-5.54). Children with positive M-CHAT-R/F scores had lower Bayley Scales of Infant and Toddler Development, Third Edition, Cognitive (t [451] = 5.43, P < .001, d = 0.82), Language (t [53.49] = 7.82, P < .001, d = 1.18), and Motor (t [451] = 7.98, P < .001, d = 1.21) composite scores and significantly greater Child Behavior Checklist Internalizing (t [457] -6.19, P < .001, d = -0.93) and Externalizing (t [57.87] = -5.62, P < .001, d = -0.84) scores. CONCLUSIONS: Positive M-CHAT-R/F screens at 2 years of corrected age were associated with neonatal medical morbidities and neurobehavioral examinations as well as toddler developmental and behavioral outcomes. These findings demonstrate the potential utility of the M-CHAT-R/F as a global developmental screener in infants born very preterm, regardless of whether there is a later autism diagnosis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Autístico Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans / Infant / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Autístico Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans / Infant / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2023 Tipo de documento: Article