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Prostate cancer genetic alterations in Hispanic men.
Arenas-Gallo, Camilo; Rhodes, Stephen; Garcia, Jorge A; Weinstein, Ilon; Prunty, Megan; Lewicki, Patrick; Brant, Aaron; Basourakos, Spyridon P; Barbieri, Christopher E; Lifschutz, Noa; Schumacher, Fredrick R; Shoag, Jonathan E.
Afiliação
  • Arenas-Gallo C; Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Rhodes S; Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Garcia JA; Department of Hematology Oncology, University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center, Cleveland, Ohio, USA.
  • Weinstein I; Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Prunty M; Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Lewicki P; Department of Urology, NewYork-Presbyterian Hospital, Weill Cornell Medicine, New York City, New York, USA.
  • Brant A; Department of Urology, NewYork-Presbyterian Hospital, Weill Cornell Medicine, New York City, New York, USA.
  • Basourakos SP; Department of Urology, NewYork-Presbyterian Hospital, Weill Cornell Medicine, New York City, New York, USA.
  • Barbieri CE; Department of Urology, NewYork-Presbyterian Hospital, Weill Cornell Medicine, New York City, New York, USA.
  • Lifschutz N; Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Schumacher FR; Department of Population Health and Quantitative Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Shoag JE; Cancer Prevention, Control & Population Research Program, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Ohio, Cleveland, USA.
Prostate ; 83(13): 1263-1269, 2023 09.
Article em En | MEDLINE | ID: mdl-37301735
ABSTRACT

BACKGROUND:

Differences in DNA alterations in prostate cancer among White, Black, and Asian men have been widely described. This is the first description of the frequency of DNA alterations in primary and metastatic prostate cancer samples of self-reported Hispanic men.

METHODS:

We utilized targeted next-generation sequencing tumor genomic profiles from prostate cancer tissues that underwent clinical sequencing at academic centers (GENIE 11th). We decided to restrict our analysis to the samples from Memorial Sloan Kettering Cancer Center as it was by far the main contributor of Hispanic samples. The numbers of men by self-reported ethnicity and racial categories were analyzed via Fisher's exact test between Hispanic-White versus non-Hispanic White. RESULTS AND

LIMITATIONS:

Our cohort consisted of 1412 primary and 818 metastatic adenocarcinomas. In primary adenocarcinomas, TMPRSS2 and ERG gene alterations were less common in non-Hispanic White men than Hispanic White (31.86% vs. 51.28%, p = 0.0007, odds ratio [OR] = 0.44 [0.27-0.72] and 25.34% vs. 42.31%, p = 0.002, OR = 0.46 [0.28-0.76]). In metastatic tumors, KRAS and CCNE1 alterations were less prevalent in non-Hispanic White men (1.03% vs. 7.50%, p = 0.014, OR = 0.13 [0.03, 0.78] and 1.29% vs. 10.00%, p = 0.003, OR = 0.12 [0.03, 0.54]). No significant differences were found in actionable alterations and androgen receptor mutations between the groups. Due to the lack of clinical characteristics and genetic ancestry in this dataset, correlation with these could not be explored.

CONCLUSION:

DNA alteration frequencies in primary and metastatic prostate cancer tumors differ among Hispanic-White and non-Hispanic White men. Notably, we found no significant differences in the prevalence of actionable genetic alterations between the groups, suggesting that a significant number of Hispanic men could benefit from the development of targeted therapies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Adenocarcinoma Tipo de estudo: Risk_factors_studies Limite: Humans / Male Idioma: En Revista: Prostate Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Adenocarcinoma Tipo de estudo: Risk_factors_studies Limite: Humans / Male Idioma: En Revista: Prostate Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos