Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia.

Kurnellas, Michael; Mitra, Ananya; Schwabe, Tina; Paul, Robert; Arrant, Andrew E; Roberson, Erik D; Ward, Michael; Yeh, Felix; Long, Hua; Rosenthal, Arnon

Kurnellas, Michael; Mitra, Ananya; Schwabe, Tina; Paul, Robert; Arrant, Andrew E; Roberson, Erik D; Ward, Michael; Yeh, Felix; Long, Hua; Rosenthal, Arnon.

Afiliação

Kurnellas M; Alector, Inc., 131 Oyster Point Blvd, #600, South San Francisco, CA, 94080, USA. mpkurnellas@gmail.com.
Mitra A; Neuron23, South San Francisco, CA, 94080, USA. mpkurnellas@gmail.com.
Schwabe T; Alector, Inc., 131 Oyster Point Blvd, #600, South San Francisco, CA, 94080, USA.
Paul R; Alector, Inc., 131 Oyster Point Blvd, #600, South San Francisco, CA, 94080, USA.
Arrant AE; Nine Square Therapeutics, Inc., South San Francisco, CA, 94080, USA.
Roberson ED; Alector, Inc., 131 Oyster Point Blvd, #600, South San Francisco, CA, 94080, USA.
Ward M; Nine Square Therapeutics, Inc., South San Francisco, CA, 94080, USA.
Yeh F; Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, and Evelyn F. McKnight Brain Institute, Departments of Neurology and Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Long H; Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, and Evelyn F. McKnight Brain Institute, Departments of Neurology and Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Rosenthal A; Alector, Inc., 131 Oyster Point Blvd, #600, South San Francisco, CA, 94080, USA.

J Transl Med ; 21(1): 387, 2023 06 15.

Article em En | MEDLINE | ID: mdl-37322482

Assuntos

Demência Frontotemporal; Humanos; Camundongos; Animais; Progranulinas/genética; Demência Frontotemporal/tratamento farmacológico; Demência Frontotemporal/genética; Demência Frontotemporal/metabolismo; Peptídeos e Proteínas de Sinalização Intercelular; Mutação/genética

Palavras-chave

Frontotemporal dementia; Latozinemab; Neuroprotection; Pharmacodynamics; Pharmacokinetics; Phase 1 clinical trial; Progranulin; Safety; Sortilin

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Demência Frontotemporal Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Transl Med Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google