In-Depth Mass Spectrometry Analysis Reveals the Plasma Proteomic and N-Glycoproteomic Impact of an Amish-Enriched Cardioprotective Variant in B4GALT1.

Zhao, Yunlong; Nayak, Shruti; Raidas, Shivkumar; Guo, Lili; Della Gatta, Giusy; Koppolu, Sujeethraj; Halasz, Gabor; Montasser, May E; Shuldiner, Alan R; Mao, Yuan; Li, Ning

Zhao, Yunlong; Nayak, Shruti; Raidas, Shivkumar; Guo, Lili; Della Gatta, Giusy; Koppolu, Sujeethraj; Halasz, Gabor; Montasser, May E; Shuldiner, Alan R; Mao, Yuan; Li, Ning.

Afiliação

Zhao Y; Analytical Chemistry Group, Regeneron Pharmaceuticals, Inc, Tarrytown, New York, USA. Electronic address: yunlong.zhao@regeneron.com.
Nayak S; Analytical Chemistry Group, Regeneron Pharmaceuticals, Inc, Tarrytown, New York, USA.
Raidas S; Analytical Chemistry Group, Regeneron Pharmaceuticals, Inc, Tarrytown, New York, USA.
Guo L; Analytical Chemistry Group, Regeneron Pharmaceuticals, Inc, Tarrytown, New York, USA.
Della Gatta G; Regeneron Genetics Center, LLC, Tarrytown, New York, USA.
Koppolu S; Molecular Profiling and Data Science, Regeneron Pharmaceuticals, Inc, Tarrytown, New York, USA.
Halasz G; Molecular Profiling and Data Science, Regeneron Pharmaceuticals, Inc, Tarrytown, New York, USA.
Montasser ME; Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Shuldiner AR; Regeneron Genetics Center, LLC, Tarrytown, New York, USA; Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Mao Y; Analytical Chemistry Group, Regeneron Pharmaceuticals, Inc, Tarrytown, New York, USA. Electronic address: yuan.mao@regeneron.com.
Li N; Analytical Chemistry Group, Regeneron Pharmaceuticals, Inc, Tarrytown, New York, USA.

Mol Cell Proteomics ; 22(8): 100595, 2023 08.

Article em En | MEDLINE | ID: mdl-37328064

Assuntos

Galactosiltransferases; Proteômica; Humanos; Amish/genética; Galactosiltransferases/genética; Galactosiltransferases/química; Galactosiltransferases/metabolismo; Glicosilação; Espectrometria de Massas em Tandem

Palavras-chave

Amish-enriched cardioprotective variant; coagulation pathway; human plasma; lipid metabolism; low-density lipoprotein; quantitative N-glycoproteomics; site-specific glycan traits analysis; tandem mass tag; ß-1,4-galactosyltransferase 1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteômica / Galactosiltransferases Limite: Humans Idioma: En Revista: Mol Cell Proteomics Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2023 Tipo de documento: Article

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