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Exercise ameliorates chronic inflammatory response induced by high-fat diet via Sestrin2 in an Nrf2-dependent manner.
Liu, Sujuan; Li, Huige; Zhang, Yukun; Song, Hualong; Fu, Li.
Afiliação
  • Liu S; Department of Anatomy and Histology, School of Basic Medical Science, Tianjin Medical University, Tianjin 300070, China.
  • Li H; Department of Physical Education, Huanghuai University, Zhumadian 463000, China.
  • Zhang Y; Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Tianjin 300070, China.
  • Song H; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China. Electronic address: tjsonghualong@sina.com.
  • Fu L; Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Tianjin 300070, China. Electronic address: lifu@tmu.edu.cn.
Biochim Biophys Acta Mol Basis Dis ; 1869(7): 166792, 2023 10.
Article em En | MEDLINE | ID: mdl-37336368
Chronic inflammation is a major contributor to the development of metabolic disorders and is commonly seen in studies of diet-induced obesity in humans and rodents. Exercise has been shown to have anti-inflammatory properties, though the exact mechanisms are still not fully understood. Sestrins and Nrf2 are of interest to researchers as they are known to protect against inflammation and oxidative stress. In this study, we aim to explore the interconnection between Sestrin2 (SESN2) and Nrf2 and their roles in exercise benefits on chronic inflammation. Our data showed that SESN2 knockout aggravated the abnormalities of body weight, fat mass, and serum lipid that were induced by a high-fat diet (HFD), and a concomitant increase of TNF-α, IL-1ß and IL-6 in both serum and skeletal muscle. Notably, exercise was found to reverse these changes, and SESN2 was found to be necessary for exercise to reduce the inflammatory response in skeletal muscles, though not in serum. Immunoprecipitation and bioinformatics prediction experiments further revealed that SESN2 directly binds to Nrf2, indicating a protein-protein interaction between the two. Furthermore, our data demonstrated that SESN2 protein is necessary for exercise-induced effects on Nrf2 pathway in HFD-fed mice, and Nrf2 protein is necessary to enable SESN2 to reduce the inflammation caused by palmitic acid (PA)+ oleic acid (OA) treatment in vitro. Our findings indicate that exercise mitigates chronic inflammation induced by HFD through SESN2 in an Nrf2-dependent manner. Our study reveals a novel molecular mechanism whereby the SESN2/Nrf2 pathway mediates the positive impact of exercise on chronic inflammation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator 2 Relacionado a NF-E2 / Dieta Hiperlipídica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Mol Basis Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator 2 Relacionado a NF-E2 / Dieta Hiperlipídica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Mol Basis Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China