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Patients who died with steatohepatitis or liver cirrhosis show neuroinflammation and neuronal loss in hippocampus.
Leone, Paola; Arenas, Yaiza M; Balzano, Tiziano; Mincheva, Gergana; Martinez-Garcia, Mar; Montoliu, Carmina; Llansola, Marta; Felipo, Vicente.
Afiliação
  • Leone P; Laboratory of Neurobiology, Centro de Investigación Príncipe Felipe, Valencia, Spain.
  • Arenas YM; Laboratory of Neurobiology, Centro de Investigación Príncipe Felipe, Valencia, Spain.
  • Balzano T; Laboratory of Neurobiology, Centro de Investigación Príncipe Felipe, Valencia, Spain.
  • Mincheva G; Centro Integral de Neurociencias, Hospital Universitario Puerta del Sur CINAC, Madrid, Spain.
  • Martinez-Garcia M; Laboratory of Neurobiology, Centro de Investigación Príncipe Felipe, Valencia, Spain.
  • Montoliu C; Laboratory of Neurobiology, Centro de Investigación Príncipe Felipe, Valencia, Spain.
  • Llansola M; Departamento de Patología, Facultad de Medicina, Universidad Valencia, Valencia, Spain.
  • Felipo V; Instituto de Investigación Sanitaria-INCLIVA, Valencia, Spain.
Eur J Neurol ; 30(10): 3032-3046, 2023 10.
Article em En | MEDLINE | ID: mdl-37340928
BACKGROUND: Neuroinflammation in the cerebral cortex of patients who died with liver cirrhosis and neuroinflammation, and neuronal death in the cerebellum of patients who died with steatohepatitis or cirrhosis, were reported. Hippocampal neuroinflammation could contribute to cognitive decline in patients with liver disease, but this has yet to be studied. The study aims were to assess if hippocampus from patients who died with steatohepatitis or cirrhosis showed: (i) glial activation, (ii) altered cytokine content, (iii) immune cell infiltration, (iv) neuronal apoptosis and (v) neuronal loss. METHODS: Post-mortem hippocampus was obtained from 6 controls, 19 patients with steatohepatitis (SH) and 4 patients with liver cirrhosis. SH patients were divided into SH1 (n = 9), SH2 (n = 6) and SH3 (n = 4) groups depending on disease severity. Glial activation, IL-1ß and TNFα content, CD4 lymphocyte and monocyte infiltration, neuronal apoptosis and neuronal loss were analyzed by immunohistochemistry. RESULTS: Patients who died in SH1 showed astrocyte activation, whereas those who died in SH2 also showed microglial activation, CD4 lymphocyte and monocyte infiltration, neuronal apoptosis and neuronal loss. These changes remained in patients in SH3, who also showed increased IL-1ß and TNFα. Patients who died of liver cirrhosis did not show CD4 lymphocyte infiltration, neuronal apoptosis or increase in TNFα, but still showed glial activation, increased IL-1ß and neuronal loss. CONCLUSIONS: Patients with steatohepatitis showed glial activation, immune cell infiltration, apoptosis and neuronal loss. Glial activation and neuronal loss remained in cirrhotic patients. This may explain the irreversibility of some cognitive alterations in hepatic encephalopathy. Cognitive reserve may contribute to different grades of cognitive impairment despite similar neuronal loss.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Necrose Tumoral alfa / Fígado Gorduroso Limite: Humans Idioma: En Revista: Eur J Neurol Assunto da revista: NEUROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Necrose Tumoral alfa / Fígado Gorduroso Limite: Humans Idioma: En Revista: Eur J Neurol Assunto da revista: NEUROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Espanha