Serum amyloid A in children and adolescents: association with overweight and carotid intima-media thickness.
Einstein (Sao Paulo)
; 21: eAO0251, 2023.
Article
em En
| MEDLINE
| ID: mdl-37341220
ABSTRACT
OBJECTIVE:
To compare serum amyloid A concentrations between overweight and eutrophic children and adolescents and to relate it to lipid profiles, glucose tolerance, and carotid intima-media thickness.METHODS:
One hundred children and adolescents (mean age 10.8±3.16 years) were included and divided into two groups overweight and non-overweight. The following were evaluated Z-score body mass index, carotid intima-media thickness, lipid metabolism biomarkers (lipid profile and apolipoproteins A1 and B), inflammatory biomarkers (ultra-sensitive C-reactive protein and serum amyloid A), and glucose homeostasis model assessment of insulin resistance.RESULTS:
The groups were homogeneous in age, sex, and pubertal stage. Higher levels of triglycerides, apolipoprotein B, homeostasis model assessment of insulin resistance, ultrasensitive C-reactive protein, serum amyloid A, and carotid intima-media thickness were observed in the overweight group. In the multivariate analysis, age (OR=1.73; 95%CI 1.16-2.60, p=0.007), Z-score body mass index (OR=3.76; 95%CI 1.64-8.59, p=0.002), apolipoprotein-B (OR=1.1; 95%CI 1.01-1.2, p=0.030), and carotid intima-media thickness (OR=5.00; 95%CI 1.38-18.04, p=0.014) were independently associated with serum amyloid A levels above the fourth quartile of the studied sample (>9.4mg/dL).CONCLUSION:
Overweight children and adolescents had higher serum amyloid A concentrations than eutrophic children. There was an independent association between higher concentrations of serum amyloid A and Z-score, body mass index, apolipoprotein B, and carotid intima-media thickness, indicating the importance of this inflammatory biomarker in identifying the early risk of atherosclerosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
/
Espessura Intima-Media Carotídea
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Humans
Idioma:
En
Revista:
Einstein (Sao Paulo)
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Brasil