Rottlerin-Liposome Inhibits the Endocytosis of Feline Coronavirus Infection.
Vet Sci
; 10(6)2023 May 30.
Article
em En
| MEDLINE
| ID: mdl-37368766
ABSTRACT
Rottlerin (R) is a natural extract from Mallotus philippensis with antiviral properties. Feline infectious peritonitis (FIP) is a fatal disease caused by feline coronavirus (FCoV) that is characterized by systemic granulomatous inflammation and high mortality. We investigated the antiviral effect of liposome-loaded R, i.e., rottlerin-liposome (RL), against FCoV. We demonstrated that RL inhibited FCoV replication in a dose-dependent manner, not only in the early endocytosis stage but also in the late stage of replication. RL resolved the low solubility issue of rottlerin and improved its inhibition efficacy at the cellular level. Based on these findings, we suggest that RL is worth further investigation as a potential treatment for FCoV.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Vet Sci
Ano de publicação:
2023
Tipo de documento:
Article