Metoclopramide loaded buccal films for potential treatment of migraine symptoms: in vitro and in vivo study.
Pharm Dev Technol
; 28(7): 650-659, 2023 Sep.
Article
em En
| MEDLINE
| ID: mdl-37395006
ABSTRACT
OBJECTIVE:
Developing mucoadhesive buccal films loaded with metoclopramide for the treatment of migraine-associated vomiting.METHODS:
Buccal films were prepared using the solvent casting method. Several tests were conducted, including measurement of film weight, thickness, drug content, moisture uptake, swelling index, and DSC analysis. The bioadhesion properties were also assessed. Furthermore, in vitro release profiles and in human bioavailability were studied.RESULTS:
The developed films were transparent, homogeneous, and easy to remove. Film weight and thickness increased with higher drug content. The drug entrapment exceeded 90%. Film weight increased with moisture uptake, and DSC analysis indicated the absence of drug crystallinity. Bioadhesion properties and swelling index decreased with increasing drug content. In vitro release demonstrated that drug release depended on the drug-polymer ratio. The in vivo study showed significant improvements in Tmax (from 1.21 ± 0.33 to 0.50 ± 0.0) and Cmax (from 45.29 ± 14.66 to 63.27 ± 24.85) compared to conventional tablets.CONCLUSION:
The prepared mucoadhesive buccal films exhibited the desired characteristics and demonstrated enhanced drug absorption, evidenced by the significantly reduced Tmax and increased Cmax compared to conventional tablets. The results indicate the successful achievement of the study objectives in selecting and designing an effective pharmaceutical dosage form. as cm2.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Metoclopramida
/
Mucosa Bucal
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Pharm Dev Technol
Assunto da revista:
FARMACIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Egito