Omentin-1 and diabetes: more evidence but far from enough.
Arch Physiol Biochem
; : 1-7, 2023 Jul 03.
Article
em En
| MEDLINE
| ID: mdl-37395595
ABSTRACT
AIMS AND BACKGROUND:
Omentin-1 (oment-1) is a type of adipokines that is mainly expressed in visceral fat tissue. Based on accumulating evidence, oment-1 is closely related to diabetes and its complications. However, so far data about oment-1 and diabetes is fragmented. In this review, we focus on the role of oment-1 on diabetes, including its possible signalling pathways, the correlation of circulating omens-1 levels with diabetes and its complications.METHODS:
The web of PubMed was searched for articles of relevant studies published until February, 2023. RESULTS ANDCONCLUSIONS:
Oment-1 might exert its effects by inhibiting the NF-κB pathway and activating the Akt and AMPK-dependent pathways. The level of circulating oment-1 is negatively correlated with the occurrence of type 2 diabetes and some complications, including diabetic vascular disease, cardiomyopathy, and retinopathy, which can be affected by anti-diabetic therapies. Oment-1 could be a promising marker for screening and targeted therapy for diabetes and its complications; however, more studies are still needed.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Revista:
Arch Physiol Biochem
Assunto da revista:
BIOQUIMICA
/
FISIOLOGIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China