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Immune functions of pattern recognition receptors in Lepidoptera.
Zhao, Lin; Niu, Jinlan; Feng, Disong; Wang, Xialu; Zhang, Rong.
Afiliação
  • Zhao L; School of Life Science and Bio-Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, China.
  • Niu J; School of Life Science and Bio-Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, China.
  • Feng D; School of Life Science and Bio-Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, China.
  • Wang X; School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, China.
  • Zhang R; School of Life Science and Bio-Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, China.
Front Immunol ; 14: 1203061, 2023.
Article em En | MEDLINE | ID: mdl-37398667
ABSTRACT
Pattern recognition receptors (PRRs), as the "sensors" in the immune response, play a prominent role in recognizing pathogen-associated molecular patterns (PAMPs) and initiating an effective defense response to pathogens in Lepidoptera. It is becoming increasingly clear that damage-associated molecular patterns (DAMPs) normally play a physiological role within cells; however, when exposed to extracellular, they may become "part-time" critical signals of the immune response. Based on research in recent years, we review herein typical PRRs of Lepidoptera, including peptidoglycan recognition protein (PGRP), gram-negative binding protein (GNBP), ß-1,3-glucan recognition protein (ßGRP), C-type lectin (CTL), and scavenger receptor (SR). We also outline the ways in which DAMPs participate in the immune response and the correlation between PRRs and immune escape. Taken together, these findings suggest that the role of PRRs in insect innate immunity may be much greater than expected and that it is possible to recognize a broader range of signaling molecules.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lepidópteros Limite: Animals Idioma: En Revista: Front Immunol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lepidópteros Limite: Animals Idioma: En Revista: Front Immunol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China