Oligodendrocyte precursor cells: the multitaskers in the brain.
Pflugers Arch
; 475(9): 1035-1044, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37401986
ABSTRACT
In the central nervous system, oligodendrocyte precursor cells (OPCs) are recognized as the progenitors responsible for the generation of oligodendrocytes, which play a critical role in myelination. Extensive research has shed light on the mechanisms underlying OPC proliferation and differentiation into mature myelin-forming oligodendrocytes. However, recent advances in the field have revealed that OPCs have multiple functions beyond their role as progenitors, exerting control over neural circuits and brain function through distinct pathways. This review aims to provide a comprehensive understanding of OPCs by first introducing their well-established features. Subsequently, we delve into the emerging roles of OPCs in modulating brain function in both healthy and diseased states. Unraveling the cellular and molecular mechanisms by which OPCs influence brain function holds great promise for identifying novel therapeutic targets for central nervous system diseases.
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Base de dados:
MEDLINE
Assunto principal:
Células Precursoras de Oligodendrócitos
Idioma:
En
Revista:
Pflugers Arch
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Alemanha