Identification of diurnal rhythmic blood markers in bronchial asthma.
ERJ Open Res
; 9(4)2023 Jul.
Article
em En
| MEDLINE
| ID: mdl-37404842
ABSTRACT
Rationale Asthma is a rhythmic inflammatory disease of the airway, regulated by the circadian clock. "Spill-over" of airway inflammation into the systemic circulation occurs in asthma and is reflected in circulating immune cell repertoire. The objective of the present study was to determine how asthma impacts peripheral blood diurnal rhythmicity. Methods:
10 healthy and 10 mild/moderate asthma participants were recruited to an overnight study. Blood was drawn every 6â h for 24â h. Mainresults:
The molecular clock in blood cells in asthma is altered; PER3 is significantly more rhythmic in asthma compared to healthy controls. Blood immune cell numbers oscillate throughout the day, in health and asthma. Peripheral blood mononucleocytes from asthma patients show significantly enhanced responses to immune stimulation and steroid suppression at 1600â h, compared to at 0400â h. Serum ceramides show complex changes in asthma some losing and others gaining rhythmicity.Conclusions:
This is the first report showing that asthma is associated with a gain in peripheral blood molecular clock rhythmicity. Whether the blood clock is responding to rhythmic signals received from the lung or driving rhythmic pathology within the lung itself is not clear. Dynamic changes occur in serum ceramides in asthma, probably reflecting systemic inflammatory action. The enhanced responses of asthma blood immune cells to glucocorticoid at 1600â h may explain why steroid administration is more effective at this time.
Texto completo:
1
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
ERJ Open Res
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Reino Unido