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Low-Dose Computed Tomography Screening in Relatives With a Family History of Lung Cancer.
Wang, Chi-Liang; Hsu, Kuo-Hsuan; Chang, Ya-Hsuan; Ho, Chao-Chi; Chiang, Chun-Ju; Chen, Kun-Chieh; Cheung, Yun-Chung; Huang, Pei-Ching; Chen, Yu-Ruei; Chen, Chih-Yi; Hsu, Chung-Ping; Hsia, Jiun-Yi; Chen, Hsuan-Yu; Yang, Shi-Yi; Li, Yao-Jen; Yang, Tsung-Ying; Tseng, Jeng-Sen; Chuang, Cheng-Yen; Hsiung, Chao A; Chen, Yuh-Min; Huang, Ming-Shyan; Yu, Chong-Jen; Chen, Kuan-Yu; Su, Wu-Chou; Chen, Jeremy J W; Yu, Sung-Liang; Chen, Chien-Jen; Yang, Pan-Chyr; Tsai, Ying-Huang; Chang, Gee-Chen.
Afiliação
  • Wang CL; Division of Pulmonary Oncology and Interventional Bronchoscopy, Department of Thoracic Medicine, Linkou Chang Gung Memorial Hospital, Medical College of Chang Gung University, Taoyuan, Taiwan.
  • Hsu KH; Division of Critical Care and Respiratory Therapy, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Chang YH; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.
  • Ho CC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; College of Medicine, National Taiwan University, Taipei, Taiwan.
  • Chiang CJ; Taiwan Cancer Registry, Taipei, Taiwan; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
  • Chen KC; Division of Pulmonary Medicine, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan; Division of Chest Medicine, De
  • Cheung YC; Department of Medical Imaging and Intervention, Linkou Chang Gung Memorial Hospital, Medical College of Chang Gung University, Taoyuan, Taiwan.
  • Huang PC; Department of Medical Imaging and Intervention, Linkou Chang Gung Memorial Hospital, Medical College of Chang Gung University, Taoyuan, Taiwan.
  • Chen YR; Department of Medical Imaging, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-Yi, Taiwan.
  • Chen CY; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Division of Thoracic Surgery, Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan.
  • Hsu CP; Division of Thoracic Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Hualien, Taiwan; Division of Thoracic Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Hsia JY; School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Division of Thoracic Surgery, Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan.
  • Chen HY; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.
  • Yang SY; Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
  • Li YJ; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
  • Yang TY; Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan.
  • Tseng JS; Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, T
  • Chuang CY; Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Hsiung CA; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
  • Chen YM; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Huang MS; Department of Internal Medicine, E-Da Cancer Hospital, Kaohsiung, Taiwan; School of Medicine, I-Shou University, Kaohsiung, Taiwan; Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Yu CJ; Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; National Taiwan University Hospital, Hsin-Chu Branch, Hsinchu, Taiwan.
  • Chen KY; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
  • Su WC; Department of Oncology, National Cheng Kung University Hospital, Tainan, Taiwan; College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Chen JJW; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
  • Yu SL; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan; Institute of Medical Device and Imaging, College of Medicine, National Taiwan
  • Chen CJ; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
  • Yang PC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; College of Medicine, National Taiwan University, Taipei, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  • Tsai YH; Department of Respiratory Therapy, Chang Gung University, Taoyuan, Taiwan; Department of Pulmonary and Critical Care, Xiamen Chang Gung Hospital, Xiamen, People's Republic of China.
  • Chang GC; Division of Pulmonary Medicine, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, T
J Thorac Oncol ; 18(11): 1492-1503, 2023 11.
Article em En | MEDLINE | ID: mdl-37414358
ABSTRACT

INTRODUCTION:

The role of a family history of lung cancer (LCFH) in screening using low-dose computed tomography (LDCT) has not been prospectively investigated with long-term follow-up.

METHODS:

A multicenter prospective study with up to three rounds of annual LDCT screening was conducted to determine the detection rate of lung cancer (LC) in asymptomatic first- or second-degree relatives of LCFH.

RESULTS:

From 2007 to 2011, there were 1102 participants enrolled, including 805 and 297 from simplex and multiplex families (MFs), respectively (54.2% women and 70.0% never-smokers). The last follow-up date was May 5, 2021. The overall LC detection rate was 4.5% (50 of 1102). The detection rate in MF was 9.4% (19 of 202) and 4.4% (4 of 91) in never-smokers and in those who smoked, respectively. The corresponding rates for simplex families were 3.7% (21 of 569) and 2.7% (6 of 223), respectively. Of these, 68.0% and 22.0% of cases with stage I and IV diseases, respectively. LC diagnoses within a 3-year interval from the initial screening tend to be younger, have a higher detection rate, and have stage I disease; thereafter, more stage III-IV disease and 66.7% (16 of 24) with negative or semipositive nodules in initial computed tomography scans. Within the 6-year interval, only maternal (modified rate ratio = 4.46, 95% confidence interval 2.32-8.56) or maternal relative history of LC (modified rate ratio = 5.41, 95% confidence interval 2.84-10.30) increased the risk of LC.

CONCLUSIONS:

LCFH is a risk factor for LC and is increased with MF history, among never-smokers, younger adults, and those with maternal relatives with LC. Randomized controlled trials are needed to confirm the mortality benefit of LDCT screening in those with LCFH.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pulmonares Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Risk_factors_studies / Screening_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: J Thorac Oncol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Taiwan
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pulmonares Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Risk_factors_studies / Screening_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: J Thorac Oncol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Taiwan