Development of prognostic models to estimate the probability of lung injury one year after COVID-19-related hospitalization-a prospective study.
J Thorac Dis
; 15(6): 2971-2983, 2023 Jun 30.
Article
em En
| MEDLINE
| ID: mdl-37426134
ABSTRACT
Background:
Long-term effects of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection still under study. The objectives of this study were to identify persistent pulmonary lesions 1 year after coronavirus disease 2019 (COVID-19) hospitalization and assess whether it is possible to estimate the probability that a patient develops these complications in the future.Methods:
A prospective study of ≥18 years old patients hospitalized for SARS-COV-2 infection who develop persistent respiratory symptoms, lung function abnormalities or have radiological findings 6-8 weeks after hospital discharge. Logistic regression models were used to identify prognostic factors associated with a higher risk of developing respiratory problems. Models performance was assessed in terms of calibration and discrimination.Results:
A total of 233 patients [median age 66 years [interquartile range (IQR) 56, 74]; 138 (59.2%) male] were categorized into two groups based on whether they stayed in the critical care unit (79 cases) or not (154). At the end of follow-up, 179 patients (76.8%) developed persistent respiratory symptoms, and 22 patients (9.4%) showed radiological fibrotic lesions with pulmonary function abnormalities (post-COVID-19 fibrotic pulmonary lesions). Our prognostic models created to predict persistent respiratory symptoms [post-COVID-19 functional status at initial visit (the higher the score, the higher the risk), and history of bronchial asthma] and post-COVID-19 fibrotic pulmonary lesions [female; FVC% (the higher the FVC%, the lower the probability); and critical care unit stay] one year after infection showed good (AUC 0.857; 95% CI 0.799-0.915) and excellent performance (AUC 0.901; 95% CI 0.837-0.964), respectively.Conclusions:
Constructed models show good performance in identifying patients at risk of developing lung injury one year after COVID-19-related hospitalization.
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Base de dados:
MEDLINE
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Thorac Dis
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Espanha