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Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy.
Le, Kang; Soth, Michael J; Cross, Jason B; Liu, Gang; Ray, William J; Ma, Jiacheng; Goodwani, Sunil G; Acton, Paul J; Buggia-Prevot, Virginie; Akkermans, Onno; Barker, John; Conner, Michael L; Jiang, Yongying; Liu, Zhen; McEwan, Paul; Warner-Schmidt, Jennifer; Xu, Alan; Zebisch, Matthias; Heijnen, Cobi J; Abrahams, Brett; Jones, Philip.
Afiliação
  • Le K; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.
  • Soth MJ; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.
  • Cross JB; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.
  • Liu G; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.
  • Ray WJ; Neurodegenerative Consortium (NDC), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.
  • Ma J; Neurodegenerative Consortium (NDC), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.
  • Goodwani SG; Neurodegenerative Consortium (NDC), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.
  • Acton PJ; Neurodegenerative Consortium (NDC), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.
  • Buggia-Prevot V; Neurodegenerative Consortium (NDC), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.
  • Akkermans O; Evotec (UK) Ltd., Abingdon, OX14 4SA, UK.
  • Barker J; Evotec (UK) Ltd., Abingdon, OX14 4SA, UK.
  • Conner ML; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.
  • Jiang Y; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.
  • Liu Z; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.
  • McEwan P; Evotec (UK) Ltd., Abingdon, OX14 4SA, UK.
  • Warner-Schmidt J; Alexandria Center for Life Science, Magnolia Neurosciences Corporation, New York, New York 10016, United States.
  • Xu A; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.
  • Zebisch M; Evotec (UK) Ltd., Abingdon, OX14 4SA, UK.
  • Heijnen CJ; Laboratories of Neuroimmunology, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.
  • Abrahams B; Department of Psychological Sciences, Rice University, Houston, Texas 77005, United States.
  • Jones P; Alexandria Center for Life Science, Magnolia Neurosciences Corporation, New York, New York 10016, United States.
J Med Chem ; 66(14): 9954-9971, 2023 07 27.
Article em En | MEDLINE | ID: mdl-37436942

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças do Sistema Nervoso Periférico / Antineoplásicos Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças do Sistema Nervoso Periférico / Antineoplásicos Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos