SIRT1 regulates osteoblast senescence through SOD2 acetylation and mitochondrial dysfunction in the progression of Osteoporosis caused by Cadmium exposure.

Zhou, Dehui; Ran, Yawei; Yu, Rui; Liu, Gang; Ran, Di; Liu, Zongping

Zhou, Dehui; Ran, Yawei; Yu, Rui; Liu, Gang; Ran, Di; Liu, Zongping.

Afiliação

Zhou D; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, PR China.
Ran Y; Medical Imaging Department, The First People's Hospital of Baiyin, Gansu, 730900, PR China.
Yu R; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, PR China.
Liu G; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, PR China; Department of Pathology & Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Ran D; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, PR China; College of Veterinary Medicine, Southwest University, Chongqing, 400715, PR China; College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA. Electronic address: diran@uic.edu.
Liu Z; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, PR China. Electronic address: liuzongping@yzu.edu.cn.

Chem Biol Interact ; 382: 110632, 2023 Sep 01.

Article em En | MEDLINE | ID: mdl-37451666

Assuntos

Cádmio; Osteoporose; Ratos; Humanos; Animais; Cádmio/toxicidade; Sirtuína 1/genética; Sirtuína 1/metabolismo; Acetilação; Senescência Celular; Osteoporose/induzido quimicamente; Osteoblastos/metabolismo; Mitocôndrias

Palavras-chave

Cadmium; DDR; Osteoblast; SIRT1; SOD2; Senescence

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoporose / Cádmio Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Chem Biol Interact Ano de publicação: 2023 Tipo de documento: Article

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