Cisplatin triggers oxidative stress, apoptosis and pro-inflammatory responses by inhibiting the SIRT1-mediated Nrf2 pathway in chondrocytes.

Hsieh, Pei-Ling; Tsai, Kun-Ling; Chou, Wan-Ching; Wu, Chin-Hsien; Jou, I-Ming; Tu, Yuan-Kun; Ma, Ching-Hou

Hsieh, Pei-Ling; Tsai, Kun-Ling; Chou, Wan-Ching; Wu, Chin-Hsien; Jou, I-Ming; Tu, Yuan-Kun; Ma, Ching-Hou.

Afiliação

Hsieh PL; Department of Anatomy, School of Medicine, China Medical University, Taichung, Taiwan.
Tsai KL; Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chou WC; Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wu CH; Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Jou IM; Department of Orthopedics, E-Da Hospital, I-Shou University, Kaohsiung City, Taiwan.
Tu YK; Department of Orthopedics, E-Da Hospital, I-Shou University, Kaohsiung City, Taiwan.
Ma CH; Department of Orthopedics, E-Da Hospital, I-Shou University, Kaohsiung City, Taiwan.

Environ Toxicol ; 38(10): 2476-2486, 2023 Oct.

Article em En | MEDLINE | ID: mdl-37497868

Assuntos

Antioxidantes; Cisplatino; Humanos; Criança; Antioxidantes/metabolismo; Cisplatino/toxicidade; Sirtuína 1/genética; Sirtuína 1/metabolismo; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo; Condrócitos/metabolismo; Estresse Oxidativo; Apoptose

Palavras-chave

SIRT1; chondrocytes; cisplatin; inflammation; oxidative stress

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cisplatino / Antioxidantes Limite: Child / Humans Idioma: En Revista: Environ Toxicol Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Taiwan

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