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Ginsenoside CK targeting KEAP1-DGR/Kelch domain disrupts the binding between KEAP1 and NRF2-DLG motif to ameliorate oxidative stress damage.
Cheng, Chuanjing; Zhang, Jinling; Liu, Kaixin; Xu, Yanyan; Shen, Fukui; Han, Yanqi; Hou, Yuanyuan; Zhang, Tiejun; Bai, Gang.
Afiliação
  • Cheng C; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.
  • Zhang J; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.
  • Liu K; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.
  • Xu Y; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.
  • Shen F; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.
  • Han Y; State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Key Laboratory of Quality markers of Traditional Chinese medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300462, China.
  • Hou Y; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China. Electronic address: houyy@nankai.edu.cn.
  • Zhang T; State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Key Laboratory of Quality markers of Traditional Chinese medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300462, China. Electronic address: zhangtj@tjipr.com.
  • Bai G; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China. Electronic address: gangbai@nankai.edu.cn.
Phytomedicine ; 119: 154992, 2023 Oct.
Article em En | MEDLINE | ID: mdl-37499433
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator 2 Relacionado a NF-E2 / Repetição Kelch Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Phytomedicine Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator 2 Relacionado a NF-E2 / Repetição Kelch Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Phytomedicine Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China