Tissue tension permits ß-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells.

Ayad, Nadia M E; Lakins, Johnathon N; Ghagre, Ajinkya; Ehrlicher, Allen J; Weaver, Valerie M

Ayad, Nadia M E; Lakins, Johnathon N; Ghagre, Ajinkya; Ehrlicher, Allen J; Weaver, Valerie M.

Afiliação

Ayad NME; Graduate Program in Bioengineering, University of California, San Francisco and University of California Berkeley, San Francisco, CA 94143, USA; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Lakins JN; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Ghagre A; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Ehrlicher AJ; Department of Bioengineering, McGill University, Montreal, QC H3A 0E9, Canada.
Weaver VM; Department of Bioengineering, Department of Anatomy and Cell Biology, Department of Biomedical Engineering, Department of Mechanical Engineering, Centre for Structural Biology, Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada.

bioRxiv ; 2023 Jul 15.

Article em En | MEDLINE | ID: mdl-37503095

Palavras-chave

Wnt signaling; cytoskeletal tension; gastrulation; gastruloids; human embryonic stem cells; mechanical forces; mechanotransduction; mesoderm specification; traction force microscopy (TFM); ß-catenin

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: BioRxiv Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: BioRxiv Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos