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Immunomodulatory actions of vitamin D in various immune-related disorders: a comprehensive review.
Ghaseminejad-Raeini, Amirhossein; Ghaderi, Ali; Sharafi, Amirmohammad; Nematollahi-Sani, Behrad; Moossavi, Maryam; Derakhshani, Afshin; Sarab, Gholamreza Anani.
Afiliação
  • Ghaseminejad-Raeini A; Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Ghaderi A; Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Sharafi A; Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Nematollahi-Sani B; Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Moossavi M; Nanobiology and Nanomedicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Derakhshani A; Laboratory of Experimental Pharmacology, IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy.
  • Sarab GA; Cellular and Molecular Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Front Immunol ; 14: 950465, 2023.
Article em En | MEDLINE | ID: mdl-37520529
For many years, vitamin D has been acknowledged for its role in maintaining calcium and phosphate balance. However, in recent years, research has assessed its immunomodulatory role and come up with conflicting conclusions. Because the vitamin D receptor is expressed in a variety of immune cell types, study into the precise role of this molecule in diseases, notably autoimmune disorders, has been made possible. The physiologically activated version of vitamin D also promotes a tolerogenic immunological condition in addition to modulating innate and acquired immune cell responses. According to a number of recent studies, this important micronutrient plays a complex role in numerous biochemical pathways in the immune system and disorders that are associated with them. Research in this field is still relatively new, and some studies claim that patients with severe autoimmune illnesses frequently have vitamin D deficiencies or insufficiencies. This review seeks to clarify the most recent research on vitamin D's immune system-related roles, including the pathophysiology of major disorders.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Vitamina D Limite: Humans Idioma: En Revista: Front Immunol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Irã

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Vitamina D Limite: Humans Idioma: En Revista: Front Immunol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Irã