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Evaluation of the MVCT-based radiomic features as prognostic factor in patients with head and neck squamous cell carcinoma.
Abe, Kota; Kadoya, Noriyuki; Ito, Kei; Tanaka, Shohei; Nakajima, Yujiro; Hashimoto, Shimpei; Suda, Yuhi; Uno, Takashi; Jingu, Keiichi.
Afiliação
  • Abe K; Department of Radiation Oncology, MR Linac ART Division, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
  • Kadoya N; Department of Radiation Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.
  • Ito K; Department of Radiation Oncology, Tohoku University Graduate School of Medicine, 1-1 Seiryo- machi, Aoba-ku, Sendai, 980-8574, Japan.
  • Tanaka S; Department of Radiation Oncology, Tohoku University Graduate School of Medicine, 1-1 Seiryo- machi, Aoba-ku, Sendai, 980-8574, Japan. kadoya.n@rad.med.tohoku.ac.jp.
  • Nakajima Y; Department of Radiation Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.
  • Hashimoto S; Department of Radiation Oncology, Tohoku University Graduate School of Medicine, 1-1 Seiryo- machi, Aoba-ku, Sendai, 980-8574, Japan.
  • Suda Y; Department of Radiation Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.
  • Uno T; Department of Radiological Sciences, Komazawa University, 1-23-1 komazawa, Setagaya-ku, Tokyo, 154-8525, Japan.
  • Jingu K; Saitama Prefectural Cancer Center, 780 large section of a town Omuro, Ina-machi, Kitaadachi- gun, Saitama, 362-0806, Japan.
BMC Med Imaging ; 23(1): 102, 2023 08 01.
Article em En | MEDLINE | ID: mdl-37528392
ABSTRACT

BACKGROUND:

Megavoltage computed tomography (MVCT) images acquired during each radiotherapy session may be useful for delta radiomics. However, no studies have examined whether the MVCT-based radiomics has prognostic power. Therefore, the purpose of this study was to examine the prognostic power of the MVCT-based radiomics for head and neck squamous cell carcinoma (HNSCC) patients.

METHODS:

100 HNSCC patients who received definitive radiotherapy were analyzed and divided into two groups training (n = 70) and test (n = 30) sets. MVCT images obtained using TomoTherapy for the first fraction of radiotherapy and planning kilovoltage CT (kVCT) images obtained using Aquilion LB CT scanner were analyzed. Primary gross tumor volume (GTV) was propagated from kVCT to MVCT images using rigid registration, and 107 radiomic features were extracted from the GTV in MVCT and kVCT images. Least absolute shrinkage and selection operator (LASSO) Cox regression model was used to examine the association between overall survival (OS) and rad score calculated for each patient by weighting the feature value through the coefficient when features were selected. Then, the predictive values of MVCT-based and kVCT-based rad score and patient-, treatment-, and tumor-specific factors were evaluated.

RESULTS:

C-indices of the rad score for MVCT- and kVCT-based radiomics were 0.667 and 0.685, respectively. The C-indices of 6 clinical factors were 0.538-0.622. The 3-year OS was significantly different between high- and low-risk groups according to the MVCT-based rad score (50% vs. 83%; p < 0.01).

CONCLUSIONS:

Our results suggested that MVCT-based radiomics had stronger prognostic power than any single clinical factor and was a useful prognostic factor when predicting OS in HNSCC patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tomografia Computadorizada por Raios X / Neoplasias de Cabeça e Pescoço Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: BMC Med Imaging Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tomografia Computadorizada por Raios X / Neoplasias de Cabeça e Pescoço Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: BMC Med Imaging Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão