Breast cancer 1 (BRCA1) protection in altered gene expression and neurodevelopmental disorders due to physiological and ethanol-enhanced reactive oxygen species formation.

Drake, Danielle M; Zhen, Danlin; Kerrebijn, Isabel; Or, Benjamin; Gao, Sophie; Afsharian, Kian; Tran, Jason; Bhatia, Shama; Cheng, Ashley; Wells, Peter G

Drake, Danielle M; Zhen, Danlin; Kerrebijn, Isabel; Or, Benjamin; Gao, Sophie; Afsharian, Kian; Tran, Jason; Bhatia, Shama; Cheng, Ashley; Wells, Peter G.

Afiliação

Drake DM; Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Centre for Pharmaceutical Oncology, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
Zhen D; Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
Kerrebijn I; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Or B; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Gao S; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
Afsharian K; Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Centre for Pharmaceutical Oncology, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
Tran J; Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
Bhatia S; Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Centre for Pharmaceutical Oncology, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
Cheng A; Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Centre for Pharmaceutical Oncology, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
Wells PG; Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Centre for Pharmaceutical Oncology, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto

Free Radic Biol Med ; 208: 272-284, 2023 11 01.

Article em En | MEDLINE | ID: mdl-37541454

Assuntos

Transtornos do Espectro Alcoólico Fetal; Neoplasias; Transtornos do Neurodesenvolvimento; Gravidez; Humanos; Feminino; Espécies Reativas de Oxigênio/metabolismo; Etanol/toxicidade; Transtornos do Espectro Alcoólico Fetal/genética; Transtornos do Espectro Alcoólico Fetal/metabolismo; Transtornos do Neurodesenvolvimento/induzido quimicamente; Transtornos do Neurodesenvolvimento/genética; Expressão Gênica; Proteína BRCA1/genética

Palavras-chave

Alcohol (ethanol); Behavioural disorders; Breast cancer 1 susceptibility gene (Brca1); DNA damage; Executive function; Fetal alcohol spectrum disorders (FASD); Gene expression; Learning and memory; Motor coordination; Neurodevelopmental disorders; Reactive oxygen species (ROS); Repetitive behaviours

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos do Espectro Alcoólico Fetal / Transtornos do Neurodesenvolvimento / Neoplasias Limite: Female / Humans / Pregnancy Idioma: En Revista: Free Radic Biol Med Assunto da revista: BIOQUIMICA / MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá

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