Repeated Low-Level Red Light Therapy for the Control of Myopia in Children: A Meta-Analysis of Randomized Controlled Trials.
Eye Contact Lens
; 49(10): 438-446, 2023 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-37565498
ABSTRACT
BACKGROUND:
Repeated low-level red light (RLRL) therapy has been suggested to be effective in children with myopia. However, evidence from randomized controlled trials (RCTs) is still limited. We performed a meta-analysis of RCTs to systematically evaluate the efficacy of RLRL on changes of axial length (AL) and cycloplegic spherical equivalent refraction (SER) in children with myopia.METHODS:
Relevant RCTs were obtained through a search of electronic databases including PubMed, Embase, Cochrane Library, Wanfang, and China National Knowledge Infrastructure from inception to September 15, 2022. A random-effects model was used to pool the results after incorporating the influence of potential heterogeneity. Subgroup analyses were performed according to the control treatment and follow-up duration.RESULTS:
A total of seven RCTs involving 1,031 children with myopia, aged 6 to 16 years, were included in the meta-analysis. Compared with control treatment without RLRL, treatment with RLRL was associated with a significantly reduced AL (mean difference [MD] -0.25 mm, 95% confidence interval [CI] -0.32 to -0.17, P <0.001; I 2 =13%) and a significantly increased cycloplegic SER (MD 0.60 D, 95% CI 0.44-0.76, P <0.001; I 2 =20%). Further subgroup analyses showed consistent results in studies comparing children wearing single vision lenses and those receiving active treatment including orthokeratology or low-dose atropine eye drops, as well as studies of treatment duration of 6 and 12 months.CONCLUSIONS:
Results of the meta-analysis suggested that RLRL treatment is effective for slowing down the progression of myopia in children aged 6 to 16 years.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fototerapia
/
Midriáticos
/
Miopia
Tipo de estudo:
Clinical_trials
/
Systematic_reviews
Limite:
Child
/
Humans
Idioma:
En
Revista:
Eye Contact Lens
Assunto da revista:
OFTALMOLOGIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China