Evaluation of cis-diamminedichloroplatinum(II) combined with metoclopramide or sodium thiosulfate on L1210 leukemia in vitro and in vivo.
Cancer Chemother Pharmacol
; 18(1): 1-4, 1986.
Article
em En
| MEDLINE
| ID: mdl-3757151
ABSTRACT
A microtiter assay was developed to monitor cytotoxic activity of drugs alone and in combination at varying ratios on a single plate. Combinations of metoclopramide or sodium thiosulfate with cis-diamminedichloroplatinum(II) (cisplatin) were evaluated in vitro and in vivo for cisplatin cytotoxicity to murine leukemia L1210. The in vitro assay indicated that metoclopramide did not interfere with cisplatin-induced cytotoxicity and confirmed previously reported inhibition of cisplatin activity by sodium thiosulfate. The drug combinations were also evaluated in vivo for antitumor activity and the results of these studies corroborated the in vitro results.
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Base de dados:
MEDLINE
Assunto principal:
Leucemia L1210
/
Protocolos de Quimioterapia Combinada Antineoplásica
Limite:
Animals
Idioma:
En
Revista:
Cancer Chemother Pharmacol
Ano de publicação:
1986
Tipo de documento:
Article