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Training the next generation of pharmacometric modelers: a multisector perspective.
Bonate, Peter L; Barrett, Jeffrey S; Ait-Oudhia, Sihem; Brundage, Richard; Corrigan, Brian; Duffull, Stephen; Gastonguay, Marc; Karlsson, Mats O; Kijima, Shinichi; Krause, Andreas; Lovern, Mark; Riggs, Matthew M; Neely, Michael; Ouellet, Daniele; Plan, Elodie L; Rao, Gauri G; Standing, Joseph; Wilkins, Justin; Zhu, Hao.
Afiliação
  • Bonate PL; Astellas, Northbrook, IL, USA. peter.bonate@astellas.com.
  • Barrett JS; Aridhia Bioinformatics, Glasgow, Scotland, UK.
  • Ait-Oudhia S; Merck & Co., Inc, Kenilworth, NJ, USA.
  • Brundage R; Metrum Research Group, University of Minnesota, Minneapolis, MN, USA.
  • Corrigan B; Pfizer, Groton, CT, USA.
  • Duffull S; Certara, Princeton, NJ, USA.
  • Gastonguay M; School of Pharmacy, University of Otago, Dunedin, New Zealand.
  • Karlsson MO; Metrum Research Group, Tariffville, CT, USA.
  • Kijima S; Department of Pharmacy, Uppsala University, Uppsala, Sweden.
  • Krause A; Office of New Drug V, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan.
  • Lovern M; Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
  • Riggs MM; Certara, Princeton, NJ, USA.
  • Neely M; Certara, Raleigh, NC, USA.
  • Ouellet D; Metrum Research Group, Tariffville, CT, USA.
  • Plan EL; Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
  • Rao GG; Janssen (Johnson & Johnson), Spring House, PA, USA.
  • Standing J; Pharmetheus, Uppsala, Sweden.
  • Wilkins J; UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
  • Zhu H; Great Ormond Street Institute of Child Health, University College London, London, UK.
J Pharmacokinet Pharmacodyn ; 51(1): 5-31, 2024 Feb.
Article em En | MEDLINE | ID: mdl-37573528
The current demand for pharmacometricians outmatches the supply provided by academic institutions and considerable investments are made to develop the competencies of these scientists on-the-job. Even with the observed increase in academic programs related to pharmacometrics, this need is unlikely to change in the foreseeable future, as the demand and scope of pharmacometrics applications keep expanding. Further, the field of pharmacometrics is changing. The field largely started when Lewis Sheiner and Stuart Beal published their seminal papers on population pharmacokinetics in the late 1970's and early 1980's and has continued to grow in impact and use since its inception. Physiological-based pharmacokinetics and systems pharmacology have grown rapidly in scope and impact in the last decade and machine learning is just on the horizon. While all these methodologies are categorized as pharmacometrics, no one person can be an expert in everything. So how do you train future pharmacometricians? Leading experts in academia, industry, contract research organizations, clinical medicine, and regulatory gave their opinions on how to best train future pharmacometricians. Their opinions were collected and synthesized to create some general recommendations.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Farmacologia Tipo de estudo: Guideline Limite: Humans Idioma: En Revista: J Pharmacokinet Pharmacodyn Assunto da revista: FARMACOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Farmacologia Tipo de estudo: Guideline Limite: Humans Idioma: En Revista: J Pharmacokinet Pharmacodyn Assunto da revista: FARMACOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos