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Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.
Neyton, Lucile P A; Patel, Ravi K; Sarma, Aartik; Willmore, Andrew; Haller, Sidney C; Kangelaris, Kirsten N; Eckalbar, Walter L; Erle, David J; Krummel, Matthew F; Hendrickson, Carolyn M; Woodruff, Prescott G; Langelier, Charles R; Calfee, Carolyn S; Fragiadakis, Gabriela K.
Afiliação
  • Neyton LPA; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, CA, USA.
  • Patel RK; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA.
  • Sarma A; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, CA, USA.
  • Willmore A; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, CA, USA.
  • Haller SC; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, CA, USA.
  • Kangelaris KN; Division of Hospital Medicine, University of California, San Francisco, CA, USA.
  • Eckalbar WL; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, CA, USA.
  • Erle DJ; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA.
  • Krummel MF; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, CA, USA.
  • Hendrickson CM; UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA.
  • Woodruff PG; Department of Medicine, University of California, San Francisco, CA, USA.
  • Langelier CR; Lung Biology Center, University of California, San Francisco, CA, USA.
  • Calfee CS; Department of Pathology, University of California, San Francisco, CA, USA.
  • Fragiadakis GK; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, CA, USA.
Res Sq ; 2023 Aug 03.
Article em En | MEDLINE | ID: mdl-37577607
ABSTRACT
Dexamethasone is the standard of care for critically ill patients with COVID-19, but the mechanisms by which it decreases mortality and its immunological effects in this setting are not understood. We performed bulk and single-cell RNA sequencing of the lower respiratory tract and blood, and plasma cytokine profiling to study the effect of dexamethasone on systemic and pulmonary immune cells. We find decreased signatures of antigen presentation, T cell recruitment, and viral injury in patients treated with dexamethasone. We identify compartment- and cell- specific differences in the effect of dexamethasone in patients with severe COVID-19 that are reproducible in publicly available datasets. Our results highlight the importance of studying compartmentalized inflammation in critically ill patients.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Res Sq Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Res Sq Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos